From e76038f84c5b6eb802ae8d57aaee86227bad5865 Mon Sep 17 00:00:00 2001 From: "Cody, Jonathan William" Date: Sun, 8 Jan 2023 17:16:16 -0600 Subject: [PATCH] Update README.md --- README.md | 17 ++++++++++++++++- 1 file changed, 16 insertions(+), 1 deletion(-) diff --git a/README.md b/README.md index 150a309..5e71822 100644 --- a/README.md +++ b/README.md @@ -1,5 +1,20 @@ # N-803_SIV_Model -ODE model of viral and immune dynamics in response to treatment of SIV with IL-15 superagonist N-803 +Jonathan W. Cody + +This repository contains all the code needed to replicate the following journal article, soon to be submitted to PLoS Computational Biology. MATLAB R2018b or later is required. + +"Mathematical modeling indicates that regulatory inhibition of CD8+ T cell cytotoxicity can limit efficacy of IL-15 immunotherapy in cases of high pre-treatment SIV viral load" +Article Authors: Jonathan W. Cody, Amy L. Ellis-Connell, Shelby L. O’Connor, Elsje Pienaar + +To replicate the article, unzip the entire repository into a folder and run the code in the following order: + + 1. "main_shared_calibration_2022_08_18.m" + 2. "main_singles_calibration_2022_09_25.m" + 3. "N803_collector_2.m" + 4. "N803_plotter_2.m" + 5. "N803_plotter_2_parameters.m" + +The following is list of files (INCOMPLETE) 'N803_model_1.m' = single-compartment model for article 1