From 8e70f02e2d1510657ec6cd62044c212c34eedcfb Mon Sep 17 00:00:00 2001 From: Qixin He Date: Wed, 16 Mar 2022 12:41:39 -0400 Subject: [PATCH] separate P into different classes --- batchRuns/ODESImmunity_v2.R | 27 +- batchRuns/ODESImmunity_v3.R | 834 + batchRuns/onelocus_paraList.csv | 25282 +++++++++++++++--------------- batchRuns/submitODE_v3.sbatch | 19 + batchRuns/v3_param.csv | 683 + 5 files changed, 14193 insertions(+), 12652 deletions(-) mode change 100644 => 100755 batchRuns/ODESImmunity_v2.R create mode 100755 batchRuns/ODESImmunity_v3.R create mode 100755 batchRuns/submitODE_v3.sbatch create mode 100644 batchRuns/v3_param.csv diff --git a/batchRuns/ODESImmunity_v2.R b/batchRuns/ODESImmunity_v2.R old mode 100644 new mode 100755 index 5d6e692..ff1f9ba --- a/batchRuns/ODESImmunity_v2.R +++ b/batchRuns/ODESImmunity_v2.R @@ -166,12 +166,12 @@ SEAI_p<-function(t,y,p){ ic_AD <- c(exp(-rAD*PW_AD/(PW_AD+PR_AD+1)), exp(-rAD*PR_AD/(PW_AD+PR_AD+1))) # converted contribution of W or R with mixed infection cost - h_NU = c((1-ic_NU[1])*(exp(-rNU)/ic_NU[1]+(1-exp(-rNU)/ic_NU[1])*(1+ResCost/2)),(1-ic_NU[2])*(exp(-rNU)/ic_NU[2]*cloneCost+(1-exp(-rNU)/ic_NU[2])*(1-mixCost/2))) - h_ND = c((1-ic_ND[1])*(exp(-rND)/ic_ND[1]+(1-exp(-rND)/ic_ND[1])*(1+ResCost/2)),(1-ic_ND[2])*(exp(-rND)/ic_ND[2]*cloneCost+(1-exp(-rND)/ic_ND[2])*(1-mixCost/2))) - h_SU = c((1-ic_SU[1])*(exp(-rSU)/ic_SU[1]+(1-exp(-rSU)/ic_SU[1])*(1+ResCost/2)),(1-ic_SU[2])*(exp(-rSU)/ic_SU[2]*cloneCost+(1-exp(-rSU)/ic_SU[2])*(1-mixCost/2))) - h_SD = c((1-ic_SD[1])*(exp(-rSD)/ic_SD[1]+(1-exp(-rSD)/ic_SD[1])*(1+ResCost/2)),(1-ic_SD[2])*(exp(-rSD)/ic_SD[2]*cloneCost+(1-exp(-rSD)/ic_SD[2])*(1-mixCost/2))) - h_AU = c((1-ic_AU[1])*(exp(-rAU)/ic_AU[1]+(1-exp(-rAU)/ic_AU[1])*(1+ResCost/2)),(1-ic_AU[2])*(exp(-rAU)/ic_AU[2]*cloneCost+(1-exp(-rAU)/ic_AU[2])*(1-mixCost/2))) - h_AD = c((1-ic_AD[1])*(exp(-rAD)/ic_AD[1]+(1-exp(-rAD)/ic_AD[1])*(1+ResCost/2)),(1-ic_AD[2])*(exp(-rAD)/ic_AD[2]*cloneCost+(1-exp(-rAD)/ic_AD[2])*(1-mixCost/2))) + h_NU = c((1-ic_NU[1])*(exp(-rNU)/ic_NU[1]+(1-exp(-rNU)/ic_NU[1])*(1+mixCost/2)),(1-ic_NU[2])*(exp(-rNU)/ic_NU[2]*cloneCost+(1-exp(-rNU)/ic_NU[2])*(1-mixCost/2))) + h_ND = c((1-ic_ND[1])*(exp(-rND)/ic_ND[1]+(1-exp(-rND)/ic_ND[1])*(1+mixCost/2)),(1-ic_ND[2])*(exp(-rND)/ic_ND[2]*cloneCost+(1-exp(-rND)/ic_ND[2])*(1-mixCost/2))) + h_SU = c((1-ic_SU[1])*(exp(-rSU)/ic_SU[1]+(1-exp(-rSU)/ic_SU[1])*(1+mixCost/2)),(1-ic_SU[2])*(exp(-rSU)/ic_SU[2]*cloneCost+(1-exp(-rSU)/ic_SU[2])*(1-mixCost/2))) + h_SD = c((1-ic_SD[1])*(exp(-rSD)/ic_SD[1]+(1-exp(-rSD)/ic_SD[1])*(1+mixCost/2)),(1-ic_SD[2])*(exp(-rSD)/ic_SD[2]*cloneCost+(1-exp(-rSD)/ic_SD[2])*(1-mixCost/2))) + h_AU = c((1-ic_AU[1])*(exp(-rAU)/ic_AU[1]+(1-exp(-rAU)/ic_AU[1])*(1+mixCost/2)),(1-ic_AU[2])*(exp(-rAU)/ic_AU[2]*cloneCost+(1-exp(-rAU)/ic_AU[2])*(1-mixCost/2))) + h_AD = c((1-ic_AD[1])*(exp(-rAD)/ic_AD[1]+(1-exp(-rAD)/ic_AD[1])*(1+mixCost/2)),(1-ic_AD[2])*(exp(-rAD)/ic_AD[2]*cloneCost+(1-exp(-rAD)/ic_AD[2])*(1-mixCost/2))) #transmissibility is reduced to the number of infected hosts, #receiving hosts needs to have open "resource room" for accepting new strains @@ -388,24 +388,29 @@ allPara<-read.csv(paramFile,sep=",",header=T) currentPara<-allPara[allPara$No==No,] -t2 = seq(from=0,to=100*365,by=1) +t2 = seq(from=0,to=30*365,by=1) N0 = c(PW_NU=100,PW_ND=0,PW_SU=0,PW_SD=0,PW_AU=0,PW_AD=0, PR_NU=2*(1-WildStrainOnly),PR_ND=0,PR_SU=0,PR_SD=0,PR_AU=0,PR_AD=0, NU=10000,ND=0,SU=0,SD=0,AU=0,AD=0, P_acc_N=0,P_acc_S=0,P_acc_A=0, b=currentPara$bavgnull*(1-currentPara$seasonality)) +print(N0) out2 = ode(y=N0,times=t2,func=SEAI_p,parms=currentPara) out2<-as_tibble(out2) sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +print(tail(sumOut2)) -while((abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/sumOut2[30,"meanP"]>0.001 )| - (abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/sumOut2[30,"meanN"]>0.001)){ - print(out2[100*365,2:23]) +print(abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)) +print(abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)) + +while((abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)>0.001 )| + (abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)>0.001)){ + print(out2[30*365,2:23]) t2<-t2+30*365 - N0 = as.numeric(out2[100*365,2:23]) + N0 = as.numeric(out2[30*365,2:23]) names(N0)<-colnames(out2[,2:23]) out2 = ode(y=N0,times=t2,func=SEAI_p,parms=currentPara) out2<-as_tibble(out2) diff --git a/batchRuns/ODESImmunity_v3.R b/batchRuns/ODESImmunity_v3.R new file mode 100755 index 0000000..0e3204f --- /dev/null +++ b/batchRuns/ODESImmunity_v3.R @@ -0,0 +1,834 @@ +require(deSolve) +library(tidyverse) +args <- commandArgs(trailingOnly = TRUE) +print(args) +paramFile<-args[1] +No<-as.integer(args[2]) +resultsFolder <-args[3] +jobid<-as.integer(args[4]) +#paramFile<-"paramList.csv" +#No<-1 +#resultsFolder<-"./" +outFile<-paste(resultsFolder,"/",strsplit(paramFile,split="[.]")[[1]][1],"_results.csv",sep="") + +SEAI_p<-function(t,y,p){ + + with(as.list(c(y,p)),{ + # total host population size + N = NU+ND+SU+SD+AU+AD + # total parasite population size + #PW = PW_NU+PW_ND+PW_SU+PW_SD+PW_AU+PW_AD + #PR = PR_NU+PR_ND+PR_SU+PR_SD+PR_AU+PR_AD + #P = PW+PR + + # parasite/host ratio + rNU = (PW_NU+PR_NU)/(NU+1) + rND = (PW_ND+PR_ND)/(ND+1) + rSU = (PW_SU+PR_SU)/(SU+1) + rSD = (PW_SD+PR_SD)/(SD+1) + rAU = (PW_AU+PR_AU)/(AU+1) + rAD = (PW_AD+PW_AD)/(AD+1) + + # prevalence + I_NU = 1-exp(-rNU) + I_ND = 1-exp(-rND) + I_SU = 1-exp(-rSU) + I_SD = 1-exp(-rSD) + I_AU = 1-exp(-rAU) + I_AD = 1-exp(-rAD) + + # individual contribution from W or R + ic_NU <- c(exp(-rNU*PW_NU/(PW_NU+PR_NU+1)), exp(-rNU*PR_NU/(PW_NU+PR_NU+1))) + ic_ND <- c(exp(-rND*PW_ND/(PW_ND+PR_ND+1)), exp(-rND*PR_ND/(PW_ND+PR_ND+1))) + ic_SU <- c(exp(-rSU*PW_SU/(PW_SU+PR_SU+1)), exp(-rSU*PR_SU/(PW_SU+PR_SU+1))) + ic_SD <- c(exp(-rSD*PW_SD/(PW_SD+PR_SD+1)), exp(-rSD*PR_SD/(PW_SD+PR_SD+1))) + ic_AU <- c(exp(-rAU*PW_AU/(PW_AU+PR_AU+1)), exp(-rAU*PR_AU/(PW_AU+PR_AU+1))) + ic_AD <- c(exp(-rAD*PW_AD/(PW_AD+PR_AD+1)), exp(-rAD*PR_AD/(PW_AD+PR_AD+1))) + + # converted contribution of W or R with mixed infection cos---- + h_NU = c((1-ic_NU[1])*(exp(-rNU)/ic_NU[1]+(1-exp(-rNU)/ic_NU[1]))+(1-ic_NU[2])*(1-exp(-rNU)/ic_NU[2])*mixCost,(1-ic_NU[2])*(exp(-rNU)/ic_NU[2]*(1-cloneCost)+(1-exp(-rNU)/ic_NU[2])*(1-mixCost))) + h_ND = c((1-ic_ND[1])*(exp(-rND)/ic_ND[1]+(1-exp(-rND)/ic_ND[1]))+(1-ic_ND[2])*(1-exp(-rND)/ic_ND[2])*mixCost,(1-ic_ND[2])*(exp(-rND)/ic_ND[2]*(1-cloneCost)+(1-exp(-rND)/ic_ND[2])*(1-mixCost))) + h_SU = c((1-ic_SU[1])*(exp(-rSU)/ic_SU[1]+(1-exp(-rSU)/ic_SU[1]))+(1-ic_SU[2])*(1-exp(-rSU)/ic_SU[2])*mixCost,(1-ic_SU[2])*(exp(-rSU)/ic_SU[2]*(1-cloneCost)+(1-exp(-rSU)/ic_SU[2])*(1-mixCost))) + h_SD = c((1-ic_SD[1])*(exp(-rSD)/ic_SD[1]+(1-exp(-rSD)/ic_SD[1]))+(1-ic_SD[2])*(1-exp(-rSD)/ic_SD[2])*mixCost,(1-ic_SD[2])*(exp(-rSD)/ic_SD[2]*(1-cloneCost)+(1-exp(-rSD)/ic_SD[2])*(1-mixCost))) + h_AU = c((1-ic_AU[1])*(exp(-rAU)/ic_AU[1]+(1-exp(-rAU)/ic_AU[1]))+(1-ic_AU[2])*(1-exp(-rAU)/ic_AU[2])*mixCost,(1-ic_AU[2])*(exp(-rAU)/ic_AU[2]*(1-cloneCost)+(1-exp(-rAU)/ic_AU[2])*(1-mixCost))) + h_AD = c((1-ic_AD[1])*(exp(-rAD)/ic_AD[1]+(1-exp(-rAD)/ic_AD[1]))+(1-ic_AD[2])*(1-exp(-rAD)/ic_AD[2])*mixCost,(1-ic_AD[2])*(exp(-rAD)/ic_AD[2]*(1-cloneCost)+(1-exp(-rAD)/ic_AD[2])*(1-mixCost))) + + #transmissibility is reduced to the number of infected hosts, + #receiving hosts needs to have open "resource room" for accepting new strains + B_PW = b*( + h_NU[1] + + h_ND[1] + + h_SU[1] + + h_SD[1] + + h_AU[1] + + h_AD[1] + ) + + B_PR = b*( + h_NU[2]+ + h_ND[2]+ + h_SU[2]+ + h_SD[2]+ + h_AU[2]+ + h_AD[2] + ) + + + + # per capita biting rate for hosts who are not treated + Bu = (B_PW+B_PR) + # per capita biting rate for hosts who are drug treated + Bd = B_PR + #print(B) + + # pop size +1 is to prevent N = 0 for undefined scenario + fracN = P_acc_N/(NU+ND+1) + fracS = P_acc_S/(SU+SD+1) + fracA = P_acc_A/(AU+AD+1) + + # probability that the infected strain has not been seen by the adaptive immune system + infN = exp(-fracN/nstrains) + infS = exp(-fracS/nstrains) + infA = exp(-fracA/nstrains) + + #naive class getting infected, and treated + NU2ND = (Bu*(1-rNU/capacity)*infN*d1) + + #naive U class getting enough # of infections to move to SU + NU2SU = (Bu*(1-rNU/capacity)*rho1*(infN*muWU+(1-infN))) + #naive U class die from infections + NUInfDie = (Bu*(1-rNU/capacity)*infN*muWU*muNU) + + #naive D class getting enough # of infections to move to SD + ND2SD = (Bd*(1-rND/capacity)*rho1*(infN*muRD+(1-infN))) + + #naive D class die from infections + NDInfDie = (Bd*(1-rND/capacity)*infN*muRD*muND) + + #SU class getting infected, show symptoms, and treated + SU2SD = (Bu*(1-rSU/capacity)*infS*d2) + + #SU class getting enough # of infections to move to AU + SU2AU = (Bu*(1-rSU/capacity)*rho2*(infS*muWU+(1-infS))) + + #SD class getting enough # of infections to move to AD + SD2AD = (Bd*(1-rSD/capacity)*rho2*(infS*muRD+(1-infS))) + + #AU class getting infected, show symptoms, and treated + AU2AD = (Bu*(1-rAU/capacity)*infA*omega*d3) + + # Parasite pop ODE------ + ## sensitive------- + dPW_NU.dt = B_PW*NU*infN*(1-rNU/capacity) + #new infections + (PW_ND/Tau)- # drug loose effectiveness + (PW_NU*NU2ND) - #naive class getting infected, and treated + (PW_NU*NU2SU) - #naive class getting enough # of infections to move to S + (PW_NU*NUInfDie)- #naive class die from infections + (PW_NU*att)- #normal death rate + (PW_NU*muWU)#clearance of infection + + + #print(dNU.dt) + + dPW_ND.dt = B_PW*ND*infN*(1-rND/capacity) + #new infections + (PW_NU*NU2ND) - #naive class getting infected, and treated + (PW_ND/Tau) - # drug loose effectiveness + (PW_ND*ND2SD) -#naive class getting enough # of infections to move to S + (PW_ND*NDInfDie) -#naive class die from infections + (PW_ND*att)- #normal death rate + (PW_ND*muWD)#clearance from drug + + #print(dND.dt) + + dPW_SU.dt = B_PW*SU*infS*(1-rSU/capacity) + #new infections + (PW_NU*NU2SU) +#naive class getting enough # of infections to move to S + (PW_SD/Tau)- # drug loose effectiveness + (PW_SU*SU2SD)- #symptomatic class getting infected, show symptoms, and treated + (PW_SU*SU2AU) -#symptomatic class getting enough # of infections to move to AU + (PW_SU*att)- #normal death rate + (PW_SU*muWU)#clearance of infection + + dPW_SD.dt = B_PW*SD*infS*(1-rSD/capacity) + #new infections + (PW_ND*ND2SD)+ #naive class getting enough # of infections to move to S + (PW_SU*SU2SD)- #symptomatic class getting infected, show symptoms, and treated + (PW_SD/Tau) - # drug loose effectiveness + (PW_SD*SD2AD)- #symptomatic class getting enough # of infections to move to AD + (PW_SD*att)- #normal death rate + (PW_SD*muWD)#clearance from drug + + dPW_AU.dt = B_PW*AU*infA*(1-rAU/capacity) + #new infections + (PW_SU*SU2AU)+ #symptomatic class getting enough # of infections to move to AU + (PW_AD/Tau)- # drug loose effectiveness + (PW_AU*AU2AD)- #asymptomatic class getting infected, show symptoms, and treated + (PW_AU*att)- #normal death rate + (PW_AU*muWU)#clearance from infection + + dPW_AD.dt = B_PW*AD*infA*(1-rAD/capacity) + #new infections + (PW_SD*SD2AD) + #symptomatic class getting enough # of infections to move to AD + (PW_AU*AU2AD)- #asymptomatic class getting infected, show symptoms, and treated + (PW_AD/Tau)- # drug loose effectiveness + (PW_AD*att)- #normal death rate + (PW_AD*muWD)#clearance from drug + + ## resistant------- + dPR_NU.dt = B_PR*NU*infN*(1-rNU/capacity) + #new infections + (PR_ND/Tau)- # drug loose effectiveness + (PR_NU*NU2ND) - #naive class getting infected, and treated + (PR_NU*NU2SU) - #naive class getting enough # of infections to move to S + (PR_NU*NUInfDie)- #naive class die from infections + (PR_NU*att)- #normal death rate + (PR_NU*muRU)#clearance of infection + + #print(dNU.dt) + + dPR_ND.dt = B_PR*ND*infN*(1-rND/capacity) + #new infections + (PR_NU*NU2ND) - #naive class getting infected, and treated + (PR_ND/Tau) - # drug loose effectiveness + (PR_ND*ND2SD) -#naive class getting enough # of infections to move to S + (PR_ND*NDInfDie) -#naive class die from infections + (PR_ND*att)- #normal death rate + (PR_ND*muRD)#clearance from drug + + #print(dND.dt) + + dPR_SU.dt = B_PR*SU*infS*(1-rSU/capacity) + #new infections + (PR_NU*NU2SU) +#naive class getting enough # of infections to move to S + (PR_SD/Tau)- # drug loose effectiveness + (PR_SU*SU2SD)- #symptomatic class getting infected, show symptoms, and treated + (PR_SU*SU2AU) -#symptomatic class getting enough # of infections to move to AU + (PR_SU*att)- #normal death rate + (PR_SU*muRU)#clearance of infection + + dPR_SD.dt = B_PR*SD*infS*(1-rSD/capacity) + #new infections + (PR_ND*ND2SD)+ #naive class getting enough # of infections to move to S + (PR_SU*SU2SD)- #symptomatic class getting infected, show symptoms, and treated + (PR_SD/Tau) - # drug loose effectiveness + (PR_SD*SD2AD)- #symptomatic class getting enough # of infections to move to AD + (PR_SD*att)- #normal death rate + (PR_SD*muRD)#clearance from drug + + dPR_AU.dt = B_PR*AU*infA*(1-rAU/capacity) + #new infections + (PR_SU*SU2AU)+ #symptomatic class getting enough # of infections to move to AU + (PR_AD/Tau)- # drug loose effectiveness + (PR_AU*AU2AD)- #asymptomatic class getting infected, show symptoms, and treated + (PR_AU*att)- #normal death rate + (PR_AU*muRU)#clearance from infection + + dPR_AD.dt = B_PR*AD*infA*(1-rAD/capacity) + #new infections + (PR_SD*SD2AD) + #symptomatic class getting enough # of infections to move to AD + (PR_AU*AU2AD)- #asymptomatic class getting infected, show symptoms, and treated + (PR_AD/Tau)- # drug loose effectiveness + (PR_AD*att)- #normal death rate + (PR_AD*muRD)#clearance from drug + + # Generalized immunity ODE------ + dNU.dt = birth + + (ND/Tau)- # drug loose effectiveness + NU*NU2ND - #naive class getting infected, and treated + NU*NU2SU - #naive class getting enough # of infections to move to S + NU*NUInfDie- #naive class die from infections + (NU*att)#normal death rate + + + #print(dNU.dt) + + dND.dt = NU*NU2ND - #naive class getting infected, and treated + (ND/Tau) - # drug loose effectiveness + ND*ND2SD -#naive class getting enough # of infections to move to S + ND*NDInfDie -#naive class die from infections + (ND*att) #normal death rate + #print(dND.dt) + + dSU.dt = NU*NU2SU +#naive class getting enough # of infections to move to S + (SD/Tau)- # drug loose effectiveness + SU*SU2SD- #symptomatic class getting infected, show symptoms, and treated + SU*SU2AU -#symptomatic class getting enough # of infections to move to AU + (SU*att) #normal death rate + + dSD.dt = ND*ND2SD+ #naive class getting enough # of infections to move to S + SU*SU2SD- #symptomatic class getting infected, show symptoms, and treated + (SD/Tau) - # drug loose effectiveness + SD*SD2AD- #symptomatic class getting enough # of infections to move to AD + (SD*att) #normal death rate + + dAU.dt = SU*SU2AU+ #symptomatic class getting enough # of infections to move to AS + (AD/Tau)- # drug loose effectiveness + AU*AU2AD- #asymptomatic class getting infected, show symptoms, and treated + (AU*att) #normal death rate + + dAD.dt = SD*SD2AD + #symptomatic class getting enough # of infections to move to AS + AU*AU2AD- #asymptomatic class getting infected, show symptoms, and treated + (AD/Tau)- # drug loose effectiveness + (AD*att) #normal death rate + + #sprintf("%.0f, %.0f,%.0f,%.0f,%.0f,%.0f",dNU.dt,dND.dt,dSU.dt,dSD.dt,dAU.dt,dAD.dt) + + # track the mean number of times infected per immunity class------ + dP_acc_N.dt = NU*Bu*(1-rNU/capacity)*(1-infN) + ND*Bd*(1-rND/capacity)*(1-infN)+ + NU*Bu*(1-rNU/capacity)*infN*muWU + ND*Bd*(1-rND/capacity)*infN*muRD- # total number of infections received + (NU*(att+NUInfDie))*fracN- #when naive U class die how many infections deducted + (ND*(att+NDInfDie))*fracN- #when naive D class die many infections deducted + (NU*NU2SU+ND*ND2SD)*fracN #when naive class leave to S + + dP_acc_S.dt = (NU*NU2SU+ND*ND2SD)*fracN+ #when naive class leave to S + SU*Bu*(1-rSU/capacity)*(infS*muWU+(1-infS)) + + SD*Bd*(1-rSD/capacity)*(infS*muRD+(1-infS))- #total number of new infections + att*P_acc_S- # normal death + (SU*SU2AU+SD*SD2AD)*fracS #Symptomatic move to Asymptomatic + + dP_acc_A.dt = (SU*SU2AU+SD*SD2AD)*fracS+ #Symptomatic move to Asymptomatic + AU*Bu*(1-rAU/capacity)*(infA*muWU+(1-infA)) + + AD*Bd*(1-rAD/capacity)*(infA*muRD+(1-infA))- #total number of new infections + (ImmLost+att)*P_acc_A # normal death + + a <- 365/(2*pi) + db.dt = bavgnull * seasonality / a *(1- dryWidth *cos(phase+t/a))*sin(phase+t/a-dryWidth*sin(phase+t/a)) + #db.dt =0 + #sprintf("%.0f, %.0f,%.0f,%.0f",dP_acc_N.dt,dP_acc_S.dt,dP_acc_A.dt,dbeta.dt) + + return(list(c(dPW_NU.dt,dPW_ND.dt,dPW_SU.dt,dPW_SD.dt,dPW_AU.dt,dPW_AD.dt, + dPR_NU.dt,dPR_ND.dt,dPR_SU.dt,dPR_SD.dt,dPR_AU.dt,dPR_AD.dt, + dNU.dt,dND.dt,dSU.dt,dSD.dt,dAU.dt,dAD.dt, + dP_acc_N.dt, dP_acc_S.dt, dP_acc_A.dt, db.dt))) + }) +} + +SEAI_wildOnly<-function(t,y,p){ + + with(as.list(c(y,p)),{ + # total host population size + N = NU+ND+SU+SD+AU+AD + # total parasite population size + #PW = PW_NU+PW_ND+PW_SU+PW_SD+PW_AU+PW_AD + #PR = PR_NU+PR_ND+PR_SU+PR_SD+PR_AU+PR_AD + #P = PW+PR + + # parasite/host ratio + rNU = (PW_NU+PR_NU)/(NU+1) + rND = (PW_ND+PR_ND)/(ND+1) + rSU = (PW_SU+PR_SU)/(SU+1) + rSD = (PW_SD+PR_SD)/(SD+1) + rAU = (PW_AU+PR_AU)/(AU+1) + rAD = (PW_AD+PW_AD)/(AD+1) + + # prevalence + I_NU = 1-exp(-rNU) + I_ND = 1-exp(-rND) + I_SU = 1-exp(-rSU) + I_SD = 1-exp(-rSD) + I_AU = 1-exp(-rAU) + I_AD = 1-exp(-rAD) + + # individual contribution from W or R + ic_NU <- c(exp(-rNU*PW_NU/(PW_NU+PR_NU+1)), exp(-rNU*PR_NU/(PW_NU+PR_NU+1))) + ic_ND <- c(exp(-rND*PW_ND/(PW_ND+PR_ND+1)), exp(-rND*PR_ND/(PW_ND+PR_ND+1))) + ic_SU <- c(exp(-rSU*PW_SU/(PW_SU+PR_SU+1)), exp(-rSU*PR_SU/(PW_SU+PR_SU+1))) + ic_SD <- c(exp(-rSD*PW_SD/(PW_SD+PR_SD+1)), exp(-rSD*PR_SD/(PW_SD+PR_SD+1))) + ic_AU <- c(exp(-rAU*PW_AU/(PW_AU+PR_AU+1)), exp(-rAU*PR_AU/(PW_AU+PR_AU+1))) + ic_AD <- c(exp(-rAD*PW_AD/(PW_AD+PR_AD+1)), exp(-rAD*PR_AD/(PW_AD+PR_AD+1))) + + # converted contribution of W or R with mixed infection cos + h_NU = c((1-ic_NU[1])*(exp(-rNU)/ic_NU[1]+(1-exp(-rNU)/ic_NU[1]))+(1-ic_NU[2])*(1-exp(-rNU)/ic_NU[2])*mixCost,(1-ic_NU[2])*(exp(-rNU)/ic_NU[2]*(1-cloneCost)+(1-exp(-rNU)/ic_NU[2])*(1-mixCost))) + h_ND = c((1-ic_ND[1])*(exp(-rND)/ic_ND[1]+(1-exp(-rND)/ic_ND[1]))+(1-ic_ND[2])*(1-exp(-rND)/ic_ND[2])*mixCost,(1-ic_ND[2])*(exp(-rND)/ic_ND[2]*(1-cloneCost)+(1-exp(-rND)/ic_ND[2])*(1-mixCost))) + h_SU = c((1-ic_SU[1])*(exp(-rSU)/ic_SU[1]+(1-exp(-rSU)/ic_SU[1]))+(1-ic_SU[2])*(1-exp(-rSU)/ic_SU[2])*mixCost,(1-ic_SU[2])*(exp(-rSU)/ic_SU[2]*(1-cloneCost)+(1-exp(-rSU)/ic_SU[2])*(1-mixCost))) + h_SD = c((1-ic_SD[1])*(exp(-rSD)/ic_SD[1]+(1-exp(-rSD)/ic_SD[1]))+(1-ic_SD[2])*(1-exp(-rSD)/ic_SD[2])*mixCost,(1-ic_SD[2])*(exp(-rSD)/ic_SD[2]*(1-cloneCost)+(1-exp(-rSD)/ic_SD[2])*(1-mixCost))) + h_AU = c((1-ic_AU[1])*(exp(-rAU)/ic_AU[1]+(1-exp(-rAU)/ic_AU[1]))+(1-ic_AU[2])*(1-exp(-rAU)/ic_AU[2])*mixCost,(1-ic_AU[2])*(exp(-rAU)/ic_AU[2]*(1-cloneCost)+(1-exp(-rAU)/ic_AU[2])*(1-mixCost))) + h_AD = c((1-ic_AD[1])*(exp(-rAD)/ic_AD[1]+(1-exp(-rAD)/ic_AD[1]))+(1-ic_AD[2])*(1-exp(-rAD)/ic_AD[2])*mixCost,(1-ic_AD[2])*(exp(-rAD)/ic_AD[2]*(1-cloneCost)+(1-exp(-rAD)/ic_AD[2])*(1-mixCost))) + + #transmissibility is reduced to the number of infected hosts, + #receiving hosts needs to have open "resource room" for accepting new strains + B_PW = b*( + h_NU[1] + + h_ND[1] + + h_SU[1] + + h_SD[1] + + h_AU[1] + + h_AD[1] + ) + + B_PR = b*( + h_NU[2]+ + h_ND[2]+ + h_SU[2]+ + h_SD[2]+ + h_AU[2]+ + h_AD[2] + ) + + + + # per capita biting rate for hosts who are not treated + Bu = (B_PW+B_PR) + # per capita biting rate for hosts who are drug treated + Bd = B_PR + #print(B) + + # pop size +1 is to prevent N = 0 for undefined scenario + fracN = P_acc_N/(NU+ND+1) + fracS = P_acc_S/(SU+SD+1) + fracA = P_acc_A/(AU+AD+1) + + # probability that the infected strain has not been seen by the adaptive immune system + infN = exp(-fracN/nstrains) + infS = exp(-fracS/nstrains) + infA = exp(-fracA/nstrains) + + #naive class getting infected, and treated + NU2ND = (Bu*(1-rNU/capacity)*infN*d1) + + #naive U class getting enough # of infections to move to SU + NU2SU = (Bu*(1-rNU/capacity)*rho1*(infN*muWU+(1-infN))) + #naive U class die from infections + NUInfDie = (Bu*(1-rNU/capacity)*infN*muWU*muNU) + + #naive D class getting enough # of infections to move to SD + ND2SD = (Bd*(1-rND/capacity)*rho1*(infN*muRD+(1-infN))) + + #naive D class die from infections + NDInfDie = (Bd*(1-rND/capacity)*infN*muRD*muND) + + #SU class getting infected, show symptoms, and treated + SU2SD = (Bu*(1-rSU/capacity)*infS*d2) + + #SU class getting enough # of infections to move to AU + SU2AU = (Bu*(1-rSU/capacity)*rho2*(infS*muWU+(1-infS))) + + #SD class getting enough # of infections to move to AD + SD2AD = (Bd*(1-rSD/capacity)*rho2*(infS*muRD+(1-infS))) + + #AU class getting infected, show symptoms, and treated + AU2AD = (Bu*(1-rAU/capacity)*infA*omega*d3) + + # Parasite pop ODE------ + ## sensitive------- + dPW_NU.dt = B_PW*NU*infN*(1-rNU/capacity) + #new infections + (PW_ND/Tau)- # drug loose effectiveness + (PW_NU*NU2ND) - #naive class getting infected, and treated + (PW_NU*NU2SU) - #naive class getting enough # of infections to move to S + (PW_NU*NUInfDie)- #naive class die from infections + (PW_NU*att)- #normal death rate + (PW_NU*muWU)#clearance of infection + + + #print(dNU.dt) + + dPW_ND.dt = B_PW*ND*infN*(1-rND/capacity) + #new infections + (PW_NU*NU2ND) - #naive class getting infected, and treated + (PW_ND/Tau) - # drug loose effectiveness + (PW_ND*ND2SD) -#naive class getting enough # of infections to move to S + (PW_ND*NDInfDie) -#naive class die from infections + (PW_ND*att)- #normal death rate + (PW_ND*muWD)#clearance from drug + + #print(dND.dt) + + dPW_SU.dt = B_PW*SU*infS*(1-rSU/capacity) + #new infections + (PW_NU*NU2SU) +#naive class getting enough # of infections to move to S + (PW_SD/Tau)- # drug loose effectiveness + (PW_SU*SU2SD)- #symptomatic class getting infected, show symptoms, and treated + (PW_SU*SU2AU) -#symptomatic class getting enough # of infections to move to AU + (PW_SU*att)- #normal death rate + (PW_SU*muWU)#clearance of infection + + dPW_SD.dt = B_PW*SD*infS*(1-rSD/capacity) + #new infections + (PW_ND*ND2SD)+ #naive class getting enough # of infections to move to S + (PW_SU*SU2SD)- #symptomatic class getting infected, show symptoms, and treated + (PW_SD/Tau) - # drug loose effectiveness + (PW_SD*SD2AD)- #symptomatic class getting enough # of infections to move to AD + (PW_SD*att)- #normal death rate + (PW_SD*muWD)#clearance from drug + + dPW_AU.dt = B_PW*AU*infA*(1-rAU/capacity) + #new infections + (PW_SU*SU2AU)+ #symptomatic class getting enough # of infections to move to AU + (PW_AD/Tau)- # drug loose effectiveness + (PW_AU*AU2AD)- #asymptomatic class getting infected, show symptoms, and treated + (PW_AU*att)- #normal death rate + (PW_AU*muWU)#clearance from infection + + dPW_AD.dt = B_PW*AD*infA*(1-rAD/capacity) + #new infections + (PW_SD*SD2AD) + #symptomatic class getting enough # of infections to move to AD + (PW_AU*AU2AD)- #asymptomatic class getting infected, show symptoms, and treated + (PW_AD/Tau)- # drug loose effectiveness + (PW_AD*att)- #normal death rate + (PW_AD*muWD)#clearance from drug + + ## resistant------- + dPR_NU.dt = 0 + + #print(dNU.dt) + + dPR_ND.dt = 0 + + #print(dND.dt) + + dPR_SU.dt = 0 + + dPR_SD.dt = 0 + + dPR_AU.dt = 0 + + dPR_AD.dt = 0 + # Generalized immunity ODE------ + dNU.dt = birth + + (ND/Tau)- # drug loose effectiveness + NU*NU2ND - #naive class getting infected, and treated + NU*NU2SU - #naive class getting enough # of infections to move to S + NU*NUInfDie- #naive class die from infections + (NU*att)#normal death rate + + + #print(dNU.dt) + + dND.dt = NU*NU2ND - #naive class getting infected, and treated + (ND/Tau) - # drug loose effectiveness + ND*ND2SD -#naive class getting enough # of infections to move to S + ND*NDInfDie -#naive class die from infections + (ND*att) #normal death rate + #print(dND.dt) + + dSU.dt = NU*NU2SU +#naive class getting enough # of infections to move to S + (SD/Tau)- # drug loose effectiveness + SU*SU2SD- #symptomatic class getting infected, show symptoms, and treated + SU*SU2AU -#symptomatic class getting enough # of infections to move to AU + (SU*att) #normal death rate + + dSD.dt = ND*ND2SD+ #naive class getting enough # of infections to move to S + SU*SU2SD- #symptomatic class getting infected, show symptoms, and treated + (SD/Tau) - # drug loose effectiveness + SD*SD2AD- #symptomatic class getting enough # of infections to move to AD + (SD*att) #normal death rate + + dAU.dt = SU*SU2AU+ #symptomatic class getting enough # of infections to move to AS + (AD/Tau)- # drug loose effectiveness + AU*AU2AD- #asymptomatic class getting infected, show symptoms, and treated + (AU*att) #normal death rate + + dAD.dt = SD*SD2AD + #symptomatic class getting enough # of infections to move to AS + AU*AU2AD- #asymptomatic class getting infected, show symptoms, and treated + (AD/Tau)- # drug loose effectiveness + (AD*att) #normal death rate + + #sprintf("%.0f, %.0f,%.0f,%.0f,%.0f,%.0f",dNU.dt,dND.dt,dSU.dt,dSD.dt,dAU.dt,dAD.dt) + + # track the mean number of times infected per immunity class------ + dP_acc_N.dt = NU*Bu*(1-rNU/capacity)*(1-infN) + ND*Bd*(1-rND/capacity)*(1-infN)+ + NU*Bu*(1-rNU/capacity)*infN*muWU + ND*Bd*(1-rND/capacity)*infN*muRD- # total number of infections received + (NU*(att+NUInfDie))*fracN- #when naive U class die how many infections deducted + (ND*(att+NDInfDie))*fracN- #when naive D class die many infections deducted + (NU*NU2SU+ND*ND2SD)*fracN #when naive class leave to S + + dP_acc_S.dt = (NU*NU2SU+ND*ND2SD)*fracN+ #when naive class leave to S + SU*Bu*(1-rSU/capacity)*(infS*muWU+(1-infS)) + + SD*Bd*(1-rSD/capacity)*(infS*muRD+(1-infS))- #total number of new infections + att*P_acc_S- # normal death + (SU*SU2AU+SD*SD2AD)*fracS #Symptomatic move to Asymptomatic + + dP_acc_A.dt = (SU*SU2AU+SD*SD2AD)*fracS+ #Symptomatic move to Asymptomatic + AU*Bu*(1-rAU/capacity)*(infA*muWU+(1-infA)) + + AD*Bd*(1-rAD/capacity)*(infA*muRD+(1-infA))- #total number of new infections + (ImmLost+att)*P_acc_A # normal death + + a <- 365/(2*pi) + db.dt = bavgnull * seasonality / a *(1- dryWidth *cos(phase+t/a))*sin(phase+t/a-dryWidth*sin(phase+t/a)) + #db.dt =0 + #sprintf("%.0f, %.0f,%.0f,%.0f",dP_acc_N.dt,dP_acc_S.dt,dP_acc_A.dt,dbeta.dt) + + return(list(c(dPW_NU.dt,dPW_ND.dt,dPW_SU.dt,dPW_SD.dt,dPW_AU.dt,dPW_AD.dt, + dPR_NU.dt,dPR_ND.dt,dPR_SU.dt,dPR_SD.dt,dPR_AU.dt,dPR_AD.dt, + dNU.dt,dND.dt,dSU.dt,dSD.dt,dAU.dt,dAD.dt, + dP_acc_N.dt, dP_acc_S.dt, dP_acc_A.dt, db.dt))) + }) +} + +allPara<-read.csv(paramFile,sep=",",header=T) + +currentPara<-allPara[allPara$No==No,] + +# Step 1 get no drug treating intensity, wildOnly----- + +currentPara$d1<-0 +currentPara$d2<-0 +currentPara$d3<-0 + +t2 = seq(from=0,to=30*365,by=1) +N0 = c(PW_NU=100,PW_ND=0,PW_SU=0,PW_SD=0,PW_AU=0,PW_AD=0, + PR_NU=0,PR_ND=0,PR_SU=0,PR_SD=0,PR_AU=0,PR_AD=0, + NU=10000,ND=0,SU=0,SD=0,AU=0,AD=0, + P_acc_N=0,P_acc_S=0,P_acc_A=0, + b=currentPara$bavgnull*(1-currentPara$seasonality)) +print(N0) +out2 = ode(y=N0,times=t2,func=SEAI_wildOnly,parms=currentPara) + +out2<-as_tibble(out2) +sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +print(tail(sumOut2)) + +print(abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)) +print(abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)) + +while((abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)>0.001 )| + (abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)>0.001)){ + print(out2[30*365,2:23]) + t2<-t2+30*365 + N0 = as.numeric(out2[30*365,2:23]) + names(N0)<-colnames(out2[,2:23]) + out2 = ode(y=N0,times=t2,func=SEAI_wildOnly,parms=currentPara) + out2<-as_tibble(out2) + sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +} +out2<-as.data.frame(out2) +out2<-out2%>%mutate(m_N = P_acc_N/(NU+ND),m_S =P_acc_S/(SU+SD), m_A = P_acc_A/(AU+AD), + PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD, + P=PW+PR,N = NU+ND+SU+SD+AU+AD, prev = 1-exp(-P/N)) + +##you can check the output through this graph +#out2.melt<-reshape2::melt(out2%>%filter(time%%10==0,time>10), id.vars=1) +#ggplot(out2.melt, aes(time,value ))+geom_line()+ylim(0,NA)+ +# facet_wrap(.~variable,scales="free_y") +outData<-as.data.frame(cbind(jobid=jobid,wildOnly=1,currentPara,tail(out2,1))) +if(file.exists(outFile)){ + write.table(outData, + file = outFile, row.names=F, col.names=F,sep=",", + quote=F,append=T) +}else{ + write.csv(outData, + file = outFile, row.names=F, + quote=F) + +} + +storeOut<-tail(out2,1)[,2:23] +# Step 2 treat occasionally, wildOnly----- + +currentPara$d1<-0.5 +currentPara$d2<-0.5 +currentPara$d3<-0.5 + +t2 = seq(from=0,to=30*365,by=1) +N0 = c(PW_NU=100,PW_ND=0,PW_SU=0,PW_SD=0,PW_AU=0,PW_AD=0, + PR_NU=0,PR_ND=0,PR_SU=0,PR_SD=0,PR_AU=0,PR_AD=0, + NU=10000,ND=0,SU=0,SD=0,AU=0,AD=0, + P_acc_N=0,P_acc_S=0,P_acc_A=0, + b=currentPara$bavgnull*(1-currentPara$seasonality)) +print(N0) +out2 = ode(y=N0,times=t2,func=SEAI_wildOnly,parms=currentPara) + +out2<-as_tibble(out2) +sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +print(tail(sumOut2)) + +print(abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)) +print(abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)) + +while((abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)>0.001 )| + (abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)>0.001)){ + print(out2[30*365,2:23]) + t2<-t2+30*365 + N0 = as.numeric(out2[30*365,2:23]) + names(N0)<-colnames(out2[,2:23]) + out2 = ode(y=N0,times=t2,func=SEAI_wildOnly,parms=currentPara) + out2<-as_tibble(out2) + sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +} +out2<-as.data.frame(out2) +out2<-out2%>%mutate(m_N = P_acc_N/(NU+ND),m_S =P_acc_S/(SU+SD), m_A = P_acc_A/(AU+AD), + PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD, + P=PW+PR,N = NU+ND+SU+SD+AU+AD, prev = 1-exp(-P/N)) + +##you can check the output through this graph +#out2.melt<-reshape2::melt(out2%>%filter(time%%10==0,time>10), id.vars=1) +#ggplot(out2.melt, aes(time,value ))+geom_line()+ylim(0,NA)+ +# facet_wrap(.~variable,scales="free_y") +outData<-as.data.frame(cbind(jobid=jobid,wildOnly=1,currentPara,tail(out2,1))) +if(file.exists(outFile)){ + write.table(outData, + file = outFile, row.names=F, col.names=F,sep=",", + quote=F,append=T) +}else{ + write.csv(outData, + file = outFile, row.names=F, + quote=F) + +} + +storeOut<-rbind(storeOut,tail(out2,1)[,2:23]) +# Step 3 full treatment, wildOnly----- + +currentPara$d1<-1 +currentPara$d2<-1 +currentPara$d3<-1 + +t2 = seq(from=0,to=30*365,by=1) +N0 = c(PW_NU=100,PW_ND=0,PW_SU=0,PW_SD=0,PW_AU=0,PW_AD=0, + PR_NU=0,PR_ND=0,PR_SU=0,PR_SD=0,PR_AU=0,PR_AD=0, + NU=10000,ND=0,SU=0,SD=0,AU=0,AD=0, + P_acc_N=0,P_acc_S=0,P_acc_A=0, + b=currentPara$bavgnull*(1-currentPara$seasonality)) +print(N0) +out2 = ode(y=N0,times=t2,func=SEAI_wildOnly,parms=currentPara) + +out2<-as_tibble(out2) +sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +print(tail(sumOut2)) + +print(abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)) +print(abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)) + +while((abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)>0.001 )| + (abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)>0.001)){ + print(out2[30*365,2:23]) + t2<-t2+30*365 + N0 = as.numeric(out2[30*365,2:23]) + names(N0)<-colnames(out2[,2:23]) + out2 = ode(y=N0,times=t2,func=SEAI_wildOnly,parms=currentPara) + out2<-as_tibble(out2) + sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +} +out2<-as.data.frame(out2) +out2<-out2%>%mutate(m_N = P_acc_N/(NU+ND),m_S =P_acc_S/(SU+SD), m_A = P_acc_A/(AU+AD), + PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD, + P=PW+PR,N = NU+ND+SU+SD+AU+AD, prev = 1-exp(-P/N)) + +##you can check the output through this graph +#out2.melt<-reshape2::melt(out2%>%filter(time%%10==0,time>10), id.vars=1) +#ggplot(out2.melt, aes(time,value ))+geom_line()+ylim(0,NA)+ +# facet_wrap(.~variable,scales="free_y") +outData<-as.data.frame(cbind(jobid=jobid,wildOnly=1,currentPara,tail(out2,1))) +if(file.exists(outFile)){ + write.table(outData, + file = outFile, row.names=F, col.names=F,sep=",", + quote=F,append=T) +}else{ + write.csv(outData, + file = outFile, row.names=F, + quote=F) + +} + +storeOut<-rbind(storeOut,tail(out2,1)[,2:23]) + +# Step 4 treat occasionally, wildOnly + resistant----- + +currentPara$d1<-0.5 +currentPara$d2<-0.5 +currentPara$d3<-0.5 + +t2 = seq(from=0,to=30*365,by=1) +N0 = unlist(storeOut[2,]) +N0["PR_NU"]<-2 +print(N0) +out2 = ode(y=N0,times=t2,func=SEAI_p,parms=currentPara) + +out2<-as_tibble(out2) +sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +print(tail(sumOut2)) + +print(abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)) +print(abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)) + +while((abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)>0.001 )| + (abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)>0.001)){ + print(out2[30*365,2:23]) + t2<-t2+30*365 + N0 = as.numeric(out2[30*365,2:23]) + names(N0)<-colnames(out2[,2:23]) + out2 = ode(y=N0,times=t2,func=SEAI_p,parms=currentPara) + out2<-as_tibble(out2) + sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +} +out2<-as.data.frame(out2) +out2<-out2%>%mutate(m_N = P_acc_N/(NU+ND),m_S =P_acc_S/(SU+SD), m_A = P_acc_A/(AU+AD), + PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD, + P=PW+PR,N = NU+ND+SU+SD+AU+AD, prev = 1-exp(-P/N)) + +##you can check the output through this graph +#out2.melt<-reshape2::melt(out2%>%filter(time%%10==0,time>10), id.vars=1) +#ggplot(out2.melt, aes(time,value ))+geom_line()+ylim(0,NA)+ +# facet_wrap(.~variable,scales="free_y") +outData<-as.data.frame(cbind(jobid=jobid,wildOnly=0,currentPara,tail(out2,1))) +if(file.exists(outFile)){ + write.table(outData, + file = outFile, row.names=F, col.names=F,sep=",", + quote=F,append=T) +}else{ + write.csv(outData, + file = outFile, row.names=F, + quote=F) + +} + +# Step 5 treat fully, wildOnly + resistant----- + +currentPara$d1<-1 +currentPara$d2<-1 +currentPara$d3<-1 + +t2 = seq(from=0,to=30*365,by=1) +N0 = unlist(storeOut[3,]) +N0["PR_NU"]<-2 +print(N0) +out2 = ode(y=N0,times=t2,func=SEAI_p,parms=currentPara) + +out2<-as_tibble(out2) +sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +print(tail(sumOut2)) + +print(abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)) +print(abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)) + +while((abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)>0.001 )| + (abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)>0.001)){ + print(out2[30*365,2:23]) + t2<-t2+30*365 + N0 = as.numeric(out2[30*365,2:23]) + names(N0)<-colnames(out2[,2:23]) + out2 = ode(y=N0,times=t2,func=SEAI_p,parms=currentPara) + out2<-as_tibble(out2) + sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +} +out2<-as.data.frame(out2) +out2<-out2%>%mutate(m_N = P_acc_N/(NU+ND),m_S =P_acc_S/(SU+SD), m_A = P_acc_A/(AU+AD), + PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD, + P=PW+PR,N = NU+ND+SU+SD+AU+AD, prev = 1-exp(-P/N)) + +##you can check the output through this graph +#out2.melt<-reshape2::melt(out2%>%filter(time%%10==0,time>10), id.vars=1) +#ggplot(out2.melt, aes(time,value ))+geom_line()+ylim(0,NA)+ +# facet_wrap(.~variable,scales="free_y") +outData<-as.data.frame(cbind(jobid=jobid,wildOnly=0,currentPara,tail(out2,1))) +if(file.exists(outFile)){ + write.table(outData, + file = outFile, row.names=F, col.names=F,sep=",", + quote=F,append=T) +}else{ + write.csv(outData, + file = outFile, row.names=F, + quote=F) + +} + diff --git a/batchRuns/onelocus_paraList.csv b/batchRuns/onelocus_paraList.csv index 069be4d..b8b2315 100644 --- a/batchRuns/onelocus_paraList.csv +++ b/batchRuns/onelocus_paraList.csv @@ -1,12643 +1,12643 @@ No,birth,att,muND,muNU,nstrains,rho1,rho2,omega,cloneCost,mixCost,ImmLost,capacity,muWU,muWD,muRD,muRU,Tau,d1,d2,d3,bavgnull,seasonality,dryWidth,phase,modelType 1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.01,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0102329299228075,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.010471285480509,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0107151930523761,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0109647819614319,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0112201845430196,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0114815362149688,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0117489755493953,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0120226443461741,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0123026877081238,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0125892541179417,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0128824955169313,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0131825673855641,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0134896288259165,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0138038426460289,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0141253754462275,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0144543977074593,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0147910838816821,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0151356124843621,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0154881661891248,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0158489319246111,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0162181009735893,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0165958690743756,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0169824365246174,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0173780082874938,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0177827941003892,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0181970085860998,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0186208713666287,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0190546071796325,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0194984459975805,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0199526231496888,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0204173794466953,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0208929613085404,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0213796208950223,0,1,0,onelocus_0 -1,1,9.13e-05,0.1,0.1,10,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.0218776162394955,0,1,0,onelocus_0 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--cpus-per-task=1 +#SBATCH --mem-per-cpu=10000 +#SBATCH --account=gcarpi +#SBATCH --mail-type=ALL +#SBATCH --mail-user=heqixin@purdue.edu + +# Print this sub-job's task ID +echo "My SLURM_ARRAY_TASK_ID: " $SLURM_ARRAY_TASK_ID +module load R + +Rscript ODESImmunity_v3.R v3_param.csv $SLURM_ARRAY_TASK_ID ./ $SLURM_JOB_ID + diff --git a/batchRuns/v3_param.csv b/batchRuns/v3_param.csv new file mode 100644 index 0000000..54c15c5 --- /dev/null +++ b/batchRuns/v3_param.csv @@ -0,0 +1,683 @@ +"No","birth","att","muND","muNU","nstrains","rho1","rho2","omega","cloneCost","mixCost","ImmLost","capacity","muWU","muWD","muRD","muRU","Tau","d1","d2","d3","bavgnull","seasonality","dryWidth","phase","modelType" +1,1,9.13e-05,0.1,0.1,6,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.001,0.95,1,0,"onelocus_0" +2,1,9.13e-05,0.1,0.1,6,0.5,0.05,0.01,0.1,0.9,0.000273973,10,0.006666667,0.99,0.006666667,0.006666667,20,1,1,1,0.00125892541179417,0.95,1,0,"onelocus_0" 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