From 96172311b29f77af7c98c55020a59808fa95fb09 Mon Sep 17 00:00:00 2001 From: Qixin He Date: Tue, 20 Sep 2022 18:13:24 -0400 Subject: [PATCH] v11 updated --- .DS_Store | Bin 8196 -> 8196 bytes ODESImmunity_v11.R | 1295 ++ batchRuns/.DS_Store | Bin 6148 -> 0 bytes .../GeneralizedImmunityExp1-old.R | 0 MalariaODEs.R => oldfiles/MalariaODEs.R | 0 .../ODESRecombination-copy.R | 0 .../ODESSeasonality (1).R | 0 .../ODESSeasonality.R | 0 .../ODEsImmunity-copy.R | 0 ODEsImmunity.R => oldfiles/ODEsImmunity.R | 0 .../ResistanceTimeSeries.R | 0 v11_combined_results.csv | 10087 ++++++++++++++++ 12 files changed, 11382 insertions(+) create mode 100644 ODESImmunity_v11.R delete mode 100644 batchRuns/.DS_Store rename GeneralizedImmunityExp1-old.R => oldfiles/GeneralizedImmunityExp1-old.R (100%) rename MalariaODEs.R => oldfiles/MalariaODEs.R (100%) rename ODESRecombination-copy.R => oldfiles/ODESRecombination-copy.R (100%) rename ODESSeasonality (1).R => oldfiles/ODESSeasonality (1).R (100%) rename 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<-args[3] +jobid<-as.integer(args[4]) +#paramFile<-"v10_param.csv" +#No<-89 +#resultsFolder<-"~/Dropbox/research/current/resistance/MalariaResistance-old/batchRuns" +#resultsFolder<-"./" +outFile<-paste(resultsFolder,"/",strsplit(paramFile,split="[.]")[[1]][1],"_",No,"_results.csv",sep="") + +SEAI_p<-function(t,y,p){ + + with(as.list(c(y,p)),{ + # total host population size + #print(t) + N = NU+ND+SU+SD+AU+AD + # total parasite population size + #PW = PW_NU+PW_ND+PW_SU+PW_SD+PW_AU+PW_AD + #PR = PR_NU+PR_ND+PR_SU+PR_SD+PR_AU+PR_AD + #P = PW+PR + + # parasite/host ratio + rNU <- (PW_NU+PR_NU)/(NU+1e-6) + rND <- (PW_ND+PR_ND)/(ND+1e-6) + rSU <- (PW_SU+PR_SU)/(SU+1e-6) + rSD <- (PW_SD+PR_SD)/(SD+1e-6) + rAU <- (PW_AU+PR_AU)/(AU+1e-6) + rAD <- (PW_AD+PW_AD)/(AD+1e-6) + + # prevalence + I_NU = 1-exp(-rNU) + I_ND = 1-exp(-rND) + I_SU = 1-exp(-rSU) + I_SD = 1-exp(-rSD) + I_AU = 1-exp(-rAU) + I_AD = 1-exp(-rAD) + + # proportion of hosts that have no parasites from W or R respectively + p0_NU <- c(exp(-rNU*PW_NU/(PW_NU+PR_NU+1e-6)), exp(-rNU*PR_NU/(PW_NU+PR_NU+1e-6))) + p0_ND <- c(exp(-rND*PW_ND/(PW_ND+PR_ND+1e-6)), exp(-rND*PR_ND/(PW_ND+PR_ND+1e-6))) + p0_SU <- c(exp(-rSU*PW_SU/(PW_SU+PR_SU+1e-6)), exp(-rSU*PR_SU/(PW_SU+PR_SU+1e-6))) + p0_SD <- c(exp(-rSD*PW_SD/(PW_SD+PR_SD+1e-6)), exp(-rSD*PR_SD/(PW_SD+PR_SD+1e-6))) + p0_AU <- c(exp(-rAU*PW_AU/(PW_AU+PR_AU+1e-6)), exp(-rAU*PR_AU/(PW_AU+PR_AU+1e-6))) + p0_AD <- c(exp(-rAD*PW_AD/(PW_AD+PR_AD+1e-6)), exp(-rAD*PR_AD/(PW_AD+PR_AD+1e-6))) + + # contributions of wild strain clones, wild strain in mixed, resistant clone and resistant mix in a bite + ctr_NU <- c(exp(-rNU)*(1/p0_NU[1]-1),(1-p0_NU[1])*(1-exp(-rNU)/p0_NU[1]),exp(-rNU)*(1/p0_NU[2]-1),(1-p0_NU[2])*(1-exp(-rNU)/p0_NU[2])) + ctr_ND <- c(exp(-rND)*(1/p0_ND[1]-1),(1-p0_ND[1])*(1-exp(-rND)/p0_ND[1]),exp(-rND)*(1/p0_ND[2]-1),(1-p0_ND[2])*(1-exp(-rND)/p0_ND[2])) + ctr_SU <- c(exp(-rSU)*(1/p0_SU[1]-1),(1-p0_SU[1])*(1-exp(-rSU)/p0_SU[1]),exp(-rSU)*(1/p0_SU[2]-1),(1-p0_SU[2])*(1-exp(-rSU)/p0_SU[2])) + ctr_SD <- c(exp(-rSD)*(1/p0_SD[1]-1),(1-p0_SD[1])*(1-exp(-rSD)/p0_SD[1]),exp(-rSD)*(1/p0_SD[2]-1),(1-p0_SD[2])*(1-exp(-rSD)/p0_SD[2])) + ctr_AU <- c(exp(-rAU)*(1/p0_AU[1]-1),(1-p0_AU[1])*(1-exp(-rAU)/p0_AU[1]),exp(-rAU)*(1/p0_AU[2]-1),(1-p0_AU[2])*(1-exp(-rAU)/p0_AU[2])) + ctr_AD <- c(exp(-rAD)*(1/p0_AD[1]-1),(1-p0_AD[1])*(1-exp(-rAD)/p0_AD[1]),exp(-rAD)*(1/p0_AD[2]-1),(1-p0_AD[2])*(1-exp(-rAD)/p0_AD[2])) + + # converted contribution of W or R with mixed infection cos---- + h_NU = c(ctr_NU[1]+ctr_NU[2]+ctr_NU[4]*(mixCost), ctr_NU[3]*(1-cloneCost)+ctr_NU[4]*(1-mixCost)) + h_ND = c(ctr_ND[1]+ctr_ND[2]+ctr_ND[4]*(mixCost), ctr_ND[3]*(1-cloneCost)+ctr_ND[4]*(1-mixCost)) + h_SU = c(ctr_SU[1]+ctr_SU[2]+ctr_SU[4]*(mixCost), ctr_SU[3]*(1-cloneCost)+ctr_SU[4]*(1-mixCost)) + h_SD = c(ctr_SD[1]+ctr_SD[2]+ctr_SD[4]*(mixCost), ctr_SD[3]*(1-cloneCost)+ctr_SD[4]*(1-mixCost)) + h_AU = c(ctr_AU[1]+ctr_AU[2]+ctr_AU[4]*(mixCost), ctr_AU[3]*(1-cloneCost)+ctr_AU[4]*(1-mixCost)) + h_AD = c(ctr_AD[1]+ctr_AD[2]+ctr_AD[4]*(mixCost), ctr_AD[3]*(1-cloneCost)+ctr_AD[4]*(1-mixCost)) + + #transmissibility is reduced to the number of infected hosts, + #receiving hosts needs to have open "resource room" for accepting new strains + B_PW = b*( + h_NU[1]*NU + + h_ND[1]*ND + + h_SU[1]*SU + + h_SD[1]*SD + + h_AU[1]*AU + + h_AD[1]*AD + )/N + + + B_PR = b*( + h_NU[2]*NU+ + h_ND[2]*ND+ + h_SU[2]*SU+ + h_SD[2]*SD+ + h_AU[2]*AU+ + h_AD[2]*AD + )/N + + + + # per capita biting rate for hosts who are not treated + Bu = (B_PW+B_PR) + # per capita biting rate for hosts who are drug treated + Bd = B_PR + #print(B) + + # pop size +1 is to prevent N = 0 for undefined scenario + fracN = P_acc_N/(NU+ND+1e-6) + fracS = P_acc_S/(SU+SD+1e-6) + fracA = P_acc_A/(AU+AD+1e-6) + + # probability that the infected strain has not been seen by the adaptive immune system + infN = (1-1/nstrains)^fracN + infS = (1-1/nstrains)^fracS + infA = (1-1/nstrains)^fracA + #print(infN) + + + #naive class getting infected, and treated + NU2ND = (Bu*(1-rNU/capacity)*infN*d1) + + #naive U class getting enough # of infections to move to SU + NU2SU = (Bu*(1-rNU/capacity)*rho1*(1-infN))+rNU*muWU*rho1 + + #naive U class die from infections + NUInfDie = rNU*muWU*muNU + + #naive D class getting enough # of infections to move to SD + ND2SD = (Bd*(1-rND/capacity)*rho1*(1-infN)) + rND*rho1*muRD + + #naive D class die from infections + NDInfDie = rND*muRD*muND + + #SU class getting infected, show symptoms, and treated + SU2SD = (Bu*(1-rSU/capacity)*infS*d2) + + #SU class getting enough # of infections to move to AU + SU2AU = Bu*(1-rSU/capacity)*rho2*(1-infS) + rSU*rho2*muWU + + #SD class getting enough # of new infections to move to AD + SD2AD = (Bd*(1-rSD/capacity)*rho2*(1-infS)) + rSD*rho2*muRD + + #AU class getting infected, show symptoms, and treated + AU2AD = (Bu*(1-rAU/capacity)*infA*omega*d3) + + #lose immunity----- + #SU back to NU due to loss of immune memory + hsu = (Bu*(1-rSU/capacity)) + SU2SD+SU2AU+att + SU2NU = hsu*exp(-hsu/ImmLost)/(1-exp(-hsu/ImmLost)) + + #SD back to ND due to loss of immune memory + hsd = (Bd*(1-rSD/capacity)) +1/Tau+att + SD2ND = hsd*exp(-hsd/ImmLost)/(1-exp(-hsd/ImmLost)) + + #AU back to SU due to loss of immune memory + hau = (Bu*(1-rAU/capacity)) + AU2AD + att + AU2SU = hau*exp(-hau/ImmLost)/(1-exp(-hau/ImmLost)) + + #AD back to SD due to loss of immune memory + had = (Bd*(1-rAD/capacity)) + 1/Tau + att + AD2SD = had*exp(-had/ImmLost)/(1-exp(-had/ImmLost)) + + # Parasite pop ODE------ + ## sensitive------- + dPW_NU.dt = B_PW*NU*infN*(1-rNU/capacity) + #new infections + PW_SU*SU2NU + # SU lose immunity back to NU + (PW_ND/Tau)- # drug loose effectiveness + (PW_NU*NU2ND) - #naive class getting infected, and treated + (PW_NU*NU2SU) - #naive class getting enough # of infections to move to S + (PW_NU*NUInfDie)- #naive class die from infections + (PW_NU*att)- #normal death rate + (PW_NU*muWU)#clearance of infection + + + #print(dNU.dt) + + dPW_ND.dt = B_PW*ND*infN*(1-rND/capacity) + #new infections + PW_SD*SD2ND + # SD lose immunity back to ND + (PW_NU*NU2ND) - #naive class getting infected, and treated + (PW_ND/Tau) - # drug loose effectiveness + (PW_ND*ND2SD) -#naive class getting enough # of infections to move to S + (PW_ND*NDInfDie) -#naive class die from infections + (PW_ND*att)- #normal death rate + (PW_ND*muWD)#clearance from drug + + #print(dND.dt) + + dPW_SU.dt = B_PW*SU*infS*(1-rSU/capacity) + #new infections + (PW_NU*NU2SU) +#naive class getting enough # of infections to move to S + (PW_AU*AU2SU) + #AU moves back to SU due to immunity loss + (PW_SD/Tau)- # drug loose effectiveness + (PW_SU*SU2SD)- #symptomatic class getting infected, show symptoms, and treated + (PW_SU*SU2AU) -#symptomatic class getting enough # of infections to move to AU + (PW_SU*SU2NU) - # lose immunity back to NU + (PW_SU*att)- #normal death rate + (PW_SU*muWU)#clearance of infection + + dPW_SD.dt = B_PW*SD*infS*(1-rSD/capacity) + #new infections + (PW_ND*ND2SD)+ #naive class getting enough # of infections to move to S + (PW_AD*AD2SD) + #AD moves back to SU due to immunity loss + (PW_SU*SU2SD)- #symptomatic class getting infected, show symptoms, and treated + (PW_SD/Tau) - # drug loose effectiveness + (PW_SD*SD2AD)- #symptomatic class getting enough # of infections to move to AD + (PW_SD*SD2ND) - # lose immunity back to ND + (PW_SD*att)- #normal death rate + (PW_SD*muWD)#clearance from drug + + dPW_AU.dt = B_PW*AU*infA*(1-rAU/capacity) + #new infections + (PW_SU*SU2AU)+ #symptomatic class getting enough # of infections to move to AU + (PW_AD/Tau)- # drug loose effectiveness + (PW_AU*AU2AD)- #asymptomatic class getting infected, show symptoms, and treated + (PW_AU*att)- #normal death rate + (PW_AU*AU2SU) - #AU moves back to SU due to immunity loss + (PW_AU*muWU)#clearance from infection + + dPW_AD.dt = B_PW*AD*infA*(1-rAD/capacity) + #new infections + (PW_SD*SD2AD) + #symptomatic class getting enough # of infections to move to AD + (PW_AU*AU2AD)- #asymptomatic class getting infected, show symptoms, and treated + (PW_AD/Tau)- # drug loose effectiveness + (PW_AD*att)- #normal death rate + (PW_AD*AD2SD) - #AD moves back to SU due to immunity loss + (PW_AD*muWD)#clearance from drug + + ## resistant------- + dPR_NU.dt = B_PR*NU*infN*(1-rNU/capacity) + #new infections + PR_SU*SU2NU + # lose immunity from SU to NU + (PR_ND/Tau)- # drug loose effectiveness + (PR_NU*NU2ND) - #naive class getting infected, and treated + (PR_NU*NU2SU) - #naive class getting enough # of infections to move to S + (PR_NU*NUInfDie)- #naive class die from infections + (PR_NU*att)- #normal death rate + (PR_NU*muRU)#clearance of infection + + #print(dNU.dt) + + dPR_ND.dt = B_PR*ND*infN*(1-rND/capacity) + #new infections + PR_SD*SD2ND + # lose immunity from SD to ND + (PR_NU*NU2ND) - #naive class getting infected, and treated + (PR_ND/Tau) - # drug loose effectiveness + (PR_ND*ND2SD) -#naive class getting enough # of infections to move to S + (PR_ND*NDInfDie) -#naive class die from infections + (PR_ND*att)- #normal death rate + (PR_ND*muRD)#clearance from drug + + #print(dND.dt) + + dPR_SU.dt = B_PR*SU*infS*(1-rSU/capacity) + #new infections + (PR_NU*NU2SU) +#naive class getting enough # of infections to move to S + (PR_AU*AU2SU) + #AU moves back to SU due to immunity loss + (PR_SD/Tau)- # drug loose effectiveness + (PR_SU*SU2SD)- #symptomatic class getting infected, show symptoms, and treated + (PR_SU*SU2AU) -#symptomatic class getting enough # of infections to move to AU + PR_SU*SU2NU - # lose immunity to NU + (PR_SU*att)- #normal death rate + (PR_SU*muRU)#clearance of infection + + dPR_SD.dt = B_PR*SD*infS*(1-rSD/capacity) + #new infections + (PR_ND*ND2SD)+ #naive class getting enough # of infections to move to S + (PR_AD*AD2SD) + #AD moves back to SD due to immunity loss + (PR_SU*SU2SD)- #symptomatic class getting infected, show symptoms, and treated + (PR_SD/Tau) - # drug loose effectiveness + (PR_SD*SD2AD)- #symptomatic class getting enough # of infections to move to AD + PR_SD*SD2ND- # lose immunity to ND + (PR_SD*att)- #normal death rate + (PR_SD*muRD)#clearance from drug + + dPR_AU.dt = B_PR*AU*infA*(1-rAU/capacity) + #new infections + (PR_SU*SU2AU)+ #symptomatic class getting enough # of infections to move to AU + (PR_AD/Tau)- # drug loose effectiveness + (PR_AU*AU2AD)- #asymptomatic class getting infected, show symptoms, and treated + (PR_AU*att)- #normal death rate + (PR_AU*AU2SU) - #AU moves back to SU due to immunity loss + (PR_AU*muRU)#clearance from infection + + dPR_AD.dt = B_PR*AD*infA*(1-rAD/capacity) + #new infections + (PR_SD*SD2AD) + #symptomatic class getting enough # of infections to move to AD + (PR_AU*AU2AD)- #asymptomatic class getting infected, show symptoms, and treated + (PR_AD/Tau)- # drug loose effectiveness + (PR_AD*att)- #normal death rate + (PR_AD*AD2SD) - #AD moves back to SD due to immunity loss + (PR_AD*muRD)#clearance from drug + + # Generalized immunity ODE------ + dNU.dt = birth + + SU*SU2NU + # lose immunity + (ND/Tau)- # drug loose effectiveness + NU*NU2ND - #naive class getting infected, and treated + NU*NU2SU - #naive class getting enough # of infections to move to S + NU*NUInfDie- #naive class die from infections + (NU*att)#normal death rate + + + #print(dNU.dt) + + dND.dt = NU*NU2ND + #naive class getting infected, and treated + SD*SD2ND - # lose immunity + (ND/Tau) - # drug loose effectiveness + ND*ND2SD -#naive class getting enough # of infections to move to S + ND*NDInfDie -#naive class die from infections + (ND*att) #normal death rate + #print(dND.dt) + + dSU.dt = NU*NU2SU +#naive class getting enough # of infections to move to S + (AU*AU2SU) + #AU moves back to SU due to immunity loss + (SD/Tau)- # drug loose effectiveness + SU*SU2SD- #symptomatic class getting infected, show symptoms, and treated + SU*SU2AU -#symptomatic class getting enough # of infections to move to AU + SU*SU2NU - # lose immunity + (SU*att) #normal death rate + + dSD.dt = ND*ND2SD+ #naive class getting enough # of infections to move to S + (AD*AD2SD) + #AD moves back to SD due to immunity loss + SU*SU2SD- #symptomatic class getting infected, show symptoms, and treated + (SD/Tau) - # drug loose effectiveness + SD*SD2AD- #symptomatic class getting enough # of infections to move to AD + SD*SD2ND - # lose immunity + (SD*att) #normal death rate + + dAU.dt = SU*SU2AU+ #symptomatic class getting enough # of infections to move to AS + (AD/Tau)- # drug loose effectiveness + AU*AU2AD- #asymptomatic class getting infected, show symptoms, and treated + (AU*AU2SU) - #AU moves back to SU due to immunity loss + (AU*att) #normal death rate + + dAD.dt = SD*SD2AD + #symptomatic class getting enough # of infections to move to AS + AU*AU2AD- #asymptomatic class getting infected, show symptoms, and treated + (AD/Tau)- # drug loose effectiveness + (AD*AD2SD) - #AD moves back to SD due to immunity loss + (AD*att) #normal death rate + + #sprintf("%.0f, %.0f,%.0f,%.0f,%.0f,%.0f",dNU.dt,dND.dt,dSU.dt,dSD.dt,dAU.dt,dAD.dt) + + # track the mean number of times infected per immunity class------ + dP_acc_N.dt = NU*NU2SU/rho1 + ND*ND2SD/rho1- # total number of infections received + (NU*(NUInfDie))*fracN- #when naive U class die how many infections deducted + (ND*(NDInfDie))*fracN- #when naive D class die many infections deducted + (NU*NU2SU+ND*ND2SD)*fracN- #when naive class leave to S + (att+ImmLost)*P_acc_N+ + (SU*SU2NU+SD*SD2ND)*fracS #immune loss back to N + + dP_acc_S.dt = (NU*NU2SU+ND*ND2SD)*fracN+ #when naive class leave to S + SU*SU2AU/rho2 + + SD*SD2AD/rho2 + #total number of new infections + (AU*AU2SU+AD*AD2SD)*fracA- #immune loss from A + (att+ImmLost)*P_acc_S- # normal death+immune loss + (SU*SU2AU+SD*SD2AD)*fracS- #Symptomatic move to Asymptomatic + (SU*SU2NU+SD*SD2ND)*fracS #immune loss back to N + + dP_acc_A.dt = (SU*SU2AU+SD*SD2AD)*fracS+ #Symptomatic move to Asymptomatic + AU*(Bu*(1-rAU/capacity)*(1-infA)+rAU*muWU) + + AD*(Bd*(1-rAD/capacity)*(1-infA)+rAD*muRD)- #total number of new infections + (att+ImmLost)*P_acc_A- # normal death + (AU*AU2SU+AD*AD2SD)*fracA #immune loss from A + + a <- 365/(2*pi) + db.dt = bavgnull * seasonality / a *(1- dryWidth *cos(phase+t/a))*sin(phase+t/a-dryWidth*sin(phase+t/a)) + + return(list(c(dPW_NU.dt,dPW_ND.dt,dPW_SU.dt,dPW_SD.dt,dPW_AU.dt,dPW_AD.dt, + dPR_NU.dt,dPR_ND.dt,dPR_SU.dt,dPR_SD.dt,dPR_AU.dt,dPR_AD.dt, + dNU.dt,dND.dt,dSU.dt,dSD.dt,dAU.dt,dAD.dt, + dP_acc_N.dt, dP_acc_S.dt, dP_acc_A.dt, db.dt))) + }) +} + +SEAI_resOnly<-function(t,y,p){ + + with(as.list(c(y,p)),{ + # total host population size + N = NU+ND+SU+SD+AU+AD + # total parasite population size + #PW = PW_NU+PW_ND+PW_SU+PW_SD+PW_AU+PW_AD + #PR = PR_NU+PR_ND+PR_SU+PR_SD+PR_AU+PR_AD + #P = PW+PR + + # parasite/host ratio + rNU <- (PW_NU+PR_NU)/(NU+1e-6) + rND <- (PW_ND+PR_ND)/(ND+1e-6) + rSU <- (PW_SU+PR_SU)/(SU+1e-6) + rSD <- (PW_SD+PR_SD)/(SD+1e-6) + rAU <- (PW_AU+PR_AU)/(AU+1e-6) + rAD <- (PW_AD+PW_AD)/(AD+1e-6) + + # prevalence + I_NU = 1-exp(-rNU) + I_ND = 1-exp(-rND) + I_SU = 1-exp(-rSU) + I_SD = 1-exp(-rSD) + I_AU = 1-exp(-rAU) + I_AD = 1-exp(-rAD) + + # proportion of hosts that have no parasites from W or R + p0_NU <- c(exp(-rNU*PW_NU/(PW_NU+PR_NU+1e-6)), exp(-rNU*PR_NU/(PW_NU+PR_NU+1e-6))) + p0_ND <- c(exp(-rND*PW_ND/(PW_ND+PR_ND+1e-6)), exp(-rND*PR_ND/(PW_ND+PR_ND+1e-6))) + p0_SU <- c(exp(-rSU*PW_SU/(PW_SU+PR_SU+1e-6)), exp(-rSU*PR_SU/(PW_SU+PR_SU+1e-6))) + p0_SD <- c(exp(-rSD*PW_SD/(PW_SD+PR_SD+1e-6)), exp(-rSD*PR_SD/(PW_SD+PR_SD+1e-6))) + p0_AU <- c(exp(-rAU*PW_AU/(PW_AU+PR_AU+1e-6)), exp(-rAU*PR_AU/(PW_AU+PR_AU+1e-6))) + p0_AD <- c(exp(-rAD*PW_AD/(PW_AD+PR_AD+1e-6)), exp(-rAD*PR_AD/(PW_AD+PR_AD+1e-6))) + + # contributions of wild strain clones, wild strain in mixed, resistant clone and resistant mix in a bite + ctr_NU <- c(exp(-rNU)*(1/p0_NU[1]-1),(1-p0_NU[1])*(1-exp(-rNU)/p0_NU[1]),exp(-rNU)*(1/p0_NU[2]-1),(1-p0_NU[2])*(1-exp(-rNU)/p0_NU[2])) + ctr_ND <- c(exp(-rND)*(1/p0_ND[1]-1),(1-p0_ND[1])*(1-exp(-rND)/p0_ND[1]),exp(-rND)*(1/p0_ND[2]-1),(1-p0_ND[2])*(1-exp(-rND)/p0_ND[2])) + ctr_SU <- c(exp(-rSU)*(1/p0_SU[1]-1),(1-p0_SU[1])*(1-exp(-rSU)/p0_SU[1]),exp(-rSU)*(1/p0_SU[2]-1),(1-p0_SU[2])*(1-exp(-rSU)/p0_SU[2])) + ctr_SD <- c(exp(-rSD)*(1/p0_SD[1]-1),(1-p0_SD[1])*(1-exp(-rSD)/p0_SD[1]),exp(-rSD)*(1/p0_SD[2]-1),(1-p0_SD[2])*(1-exp(-rSD)/p0_SD[2])) + ctr_AU <- c(exp(-rAU)*(1/p0_AU[1]-1),(1-p0_AU[1])*(1-exp(-rAU)/p0_AU[1]),exp(-rAU)*(1/p0_AU[2]-1),(1-p0_AU[2])*(1-exp(-rAU)/p0_AU[2])) + ctr_AD <- c(exp(-rAD)*(1/p0_AD[1]-1),(1-p0_AD[1])*(1-exp(-rAD)/p0_AD[1]),exp(-rAD)*(1/p0_AD[2]-1),(1-p0_AD[2])*(1-exp(-rAD)/p0_AD[2])) + + # converted contribution of W or R with mixed infection cos---- + h_NU = c(ctr_NU[1]+ctr_NU[2]+ctr_NU[4]*(mixCost), ctr_NU[3]*(1-cloneCost)+ctr_NU[4]*(1-mixCost)) + h_ND = c(ctr_ND[1]+ctr_ND[2]+ctr_ND[4]*(mixCost), ctr_ND[3]*(1-cloneCost)+ctr_ND[4]*(1-mixCost)) + h_SU = c(ctr_SU[1]+ctr_SU[2]+ctr_SU[4]*(mixCost), ctr_SU[3]*(1-cloneCost)+ctr_SU[4]*(1-mixCost)) + h_SD = c(ctr_SD[1]+ctr_SD[2]+ctr_SD[4]*(mixCost), ctr_SD[3]*(1-cloneCost)+ctr_SD[4]*(1-mixCost)) + h_AU = c(ctr_AU[1]+ctr_AU[2]+ctr_AU[4]*(mixCost), ctr_AU[3]*(1-cloneCost)+ctr_AU[4]*(1-mixCost)) + h_AD = c(ctr_AD[1]+ctr_AD[2]+ctr_AD[4]*(mixCost), ctr_AD[3]*(1-cloneCost)+ctr_AD[4]*(1-mixCost)) + + #transmissibility is reduced to the number of infected hosts, + #receiving hosts needs to have open "resource room" for accepting new strains + B_PW = b*( + h_NU[1]*NU + + h_ND[1]*ND + + h_SU[1]*SU + + h_SD[1]*SD + + h_AU[1]*AU + + h_AD[1]*AD + )/N + + + B_PR = b*( + h_NU[2]*NU+ + h_ND[2]*ND+ + h_SU[2]*SU+ + h_SD[2]*SD+ + h_AU[2]*AU+ + h_AD[2]*AD + )/N + + + # per capita biting rate for hosts who are not treated + Bu = (B_PW+B_PR) + # per capita biting rate for hosts who are drug treated + Bd = B_PR + #print(B) + + # pop size +1 is to prevent N = 0 for undefined scenario + fracN = P_acc_N/(NU+ND+1e-6) + fracS = P_acc_S/(SU+SD+1e-6) + fracA = P_acc_A/(AU+AD+1e-6) + + # probability that the infected strain has not been seen by the adaptive immune system + infN = (1-1/nstrains)^fracN + infS = (1-1/nstrains)^fracS + infA = (1-1/nstrains)^fracA + + #naive class getting infected, and treated + NU2ND = (Bu*(1-rNU/capacity)*infN*d1) + + #naive U class getting enough # of infections to move to SU + NU2SU = (Bu*(1-rNU/capacity)*rho1*(1-infN))+rNU*muWU*rho1 + + #naive U class die from infections + NUInfDie = rNU*muWU*muNU + + #naive D class getting enough # of infections to move to SD + ND2SD = (Bd*(1-rND/capacity)*rho1*(1-infN)) + rND*rho1*muRD + + #naive D class die from infections + NDInfDie = rND*muRD*muND + + #SU class getting infected, show symptoms, and treated + SU2SD = (Bu*(1-rSU/capacity)*infS*d2) + + #SU class getting enough # of infections to move to AU + SU2AU = Bu*(1-rSU/capacity)*rho2*(1-infS) + rSU*rho2*muWU + + #SD class getting enough # of new infections to move to AD + SD2AD = (Bd*(1-rSD/capacity)*rho2*(1-infS)) + rSD*rho2*muRD + + #AU class getting infected, show symptoms, and treated + AU2AD = (Bu*(1-rAU/capacity)*infA*omega*d3) + + #lose immunity----- + #SU back to NU due to loss of immune memory + hsu = (Bu*(1-rSU/capacity)) + SU2SD+SU2AU+att + SU2NU = hsu*exp(-hsu/ImmLost)/(1-exp(-hsu/ImmLost)) + + #SD back to ND due to loss of immune memory + hsd = (Bd*(1-rSD/capacity)) +1/Tau+att + SD2ND = hsd*exp(-hsd/ImmLost)/(1-exp(-hsd/ImmLost)) + + #AU back to SU due to loss of immune memory + hau = (Bu*(1-rAU/capacity)) + AU2AD + att + AU2SU = hau*exp(-hau/ImmLost)/(1-exp(-hau/ImmLost)) + + #AD back to SD due to loss of immune memory + had = (Bd*(1-rAD/capacity)) + 1/Tau + att + AD2SD = had*exp(-had/ImmLost)/(1-exp(-had/ImmLost)) + + # Parasite pop ODE------ + ## sensitive------- + dPW_NU.dt = 0 + + #print(dNU.dt) + + dPW_ND.dt = 0 + + #print(dND.dt) + + dPW_SU.dt = 0 + + dPW_SD.dt = 0 + + dPW_AU.dt = 0 + + dPW_AD.dt = 0 + + ## resistant------- + dPR_NU.dt = B_PR*NU*infN*(1-rNU/capacity) + #new infections + PR_SU*SU2NU + # lose immunity from SU to NU + (PR_ND/Tau)- # drug loose effectiveness + (PR_NU*NU2ND) - #naive class getting infected, and treated + (PR_NU*NU2SU) - #naive class getting enough # of infections to move to S + (PR_NU*NUInfDie)- #naive class die from infections + (PR_NU*att)- #normal death rate + (PR_NU*muRU)#clearance of infection + + #print(dNU.dt) + + dPR_ND.dt = B_PR*ND*infN*(1-rND/capacity) + #new infections + PR_SD*SD2ND + # lose immunity from SD to ND + (PR_NU*NU2ND) - #naive class getting infected, and treated + (PR_ND/Tau) - # drug loose effectiveness + (PR_ND*ND2SD) -#naive class getting enough # of infections to move to S + (PR_ND*NDInfDie) -#naive class die from infections + (PR_ND*att)- #normal death rate + (PR_ND*muRD)#clearance from drug + + #print(dND.dt) + + dPR_SU.dt = B_PR*SU*infS*(1-rSU/capacity) + #new infections + (PR_NU*NU2SU) +#naive class getting enough # of infections to move to S + (PR_AU*AU2SU) + #AU moves back to SU due to immunity loss + (PR_SD/Tau)- # drug loose effectiveness + (PR_SU*SU2SD)- #symptomatic class getting infected, show symptoms, and treated + (PR_SU*SU2AU) -#symptomatic class getting enough # of infections to move to AU + PR_SU*SU2NU - # lose immunity to NU + (PR_SU*att)- #normal death rate + (PR_SU*muRU)#clearance of infection + + dPR_SD.dt = B_PR*SD*infS*(1-rSD/capacity) + #new infections + (PR_ND*ND2SD)+ #naive class getting enough # of infections to move to S + (PR_AD*AD2SD) + #AD moves back to SD due to immunity loss + (PR_SU*SU2SD)- #symptomatic class getting infected, show symptoms, and treated + (PR_SD/Tau) - # drug loose effectiveness + (PR_SD*SD2AD)- #symptomatic class getting enough # of infections to move to AD + PR_SD*SD2ND- # lose immunity to ND + (PR_SD*att)- #normal death rate + (PR_SD*muRD)#clearance from drug + + dPR_AU.dt = B_PR*AU*infA*(1-rAU/capacity) + #new infections + (PR_SU*SU2AU)+ #symptomatic class getting enough # of infections to move to AU + (PR_AD/Tau)- # drug loose effectiveness + (PR_AU*AU2AD)- #asymptomatic class getting infected, show symptoms, and treated + (PR_AU*att)- #normal death rate + (PR_AU*AU2SU) - #AU moves back to SU due to immunity loss + (PR_AU*muRU)#clearance from infection + + dPR_AD.dt = B_PR*AD*infA*(1-rAD/capacity) + #new infections + (PR_SD*SD2AD) + #symptomatic class getting enough # of infections to move to AD + (PR_AU*AU2AD)- #asymptomatic class getting infected, show symptoms, and treated + (PR_AD/Tau)- # drug loose effectiveness + (PR_AD*att)- #normal death rate + (PR_AD*AD2SD) - #AD moves back to SD due to immunity loss + (PR_AD*muRD)#clearance from drug + + # Generalized immunity ODE------ + dNU.dt = birth + + SU*SU2NU + # lose immunity + (ND/Tau)- # drug loose effectiveness + NU*NU2ND - #naive class getting infected, and treated + NU*NU2SU - #naive class getting enough # of infections to move to S + NU*NUInfDie- #naive class die from infections + (NU*att)#normal death rate + + + #print(dNU.dt) + + dND.dt = NU*NU2ND + #naive class getting infected, and treated + SD*SD2ND - # lose immunity + (ND/Tau) - # drug loose effectiveness + ND*ND2SD -#naive class getting enough # of infections to move to S + ND*NDInfDie -#naive class die from infections + (ND*att) #normal death rate + #print(dND.dt) + + dSU.dt = NU*NU2SU +#naive class getting enough # of infections to move to S + (AU*AU2SU) + #AU moves back to SU due to immunity loss + (SD/Tau)- # drug loose effectiveness + SU*SU2SD- #symptomatic class getting infected, show symptoms, and treated + SU*SU2AU -#symptomatic class getting enough # of infections to move to AU + SU*SU2NU - # lose immunity + (SU*att) #normal death rate + + dSD.dt = ND*ND2SD+ #naive class getting enough # of infections to move to S + (AD*AD2SD) + #AD moves back to SD due to immunity loss + SU*SU2SD- #symptomatic class getting infected, show symptoms, and treated + (SD/Tau) - # drug loose effectiveness + SD*SD2AD- #symptomatic class getting enough # of infections to move to AD + SD*SD2ND - # lose immunity + (SD*att) #normal death rate + + dAU.dt = SU*SU2AU+ #symptomatic class getting enough # of infections to move to AS + (AD/Tau)- # drug loose effectiveness + AU*AU2AD- #asymptomatic class getting infected, show symptoms, and treated + (AU*AU2SU) - #AU moves back to SU due to immunity loss + (AU*att) #normal death rate + + dAD.dt = SD*SD2AD + #symptomatic class getting enough # of infections to move to AS + AU*AU2AD- #asymptomatic class getting infected, show symptoms, and treated + (AD/Tau)- # drug loose effectiveness + (AD*AD2SD) - #AD moves back to SD due to immunity loss + (AD*att) #normal death rate + + #sprintf("%.0f, %.0f,%.0f,%.0f,%.0f,%.0f",dNU.dt,dND.dt,dSU.dt,dSD.dt,dAU.dt,dAD.dt) + + # track the mean number of times infected per immunity class------ + dP_acc_N.dt = NU*NU2SU/rho1 + ND*ND2SD/rho1- # total number of infections received + (NU*(NUInfDie))*fracN- #when naive U class die how many infections deducted + (ND*(NDInfDie))*fracN- #when naive D class die many infections deducted + (NU*NU2SU+ND*ND2SD)*fracN- #when naive class leave to S + (att+ImmLost)*P_acc_N+ + (SU*SU2NU+SD*SD2ND)*fracS #immune loss back to N + + dP_acc_S.dt = (NU*NU2SU+ND*ND2SD)*fracN+ #when naive class leave to S + SU*SU2AU/rho2 + + SD*SD2AD/rho2 + #total number of new infections + (AU*AU2SU+AD*AD2SD)*fracA- #immune loss from A + (att+ImmLost)*P_acc_S- # normal death+immune loss + (SU*SU2AU+SD*SD2AD)*fracS- #Symptomatic move to Asymptomatic + (SU*SU2NU+SD*SD2ND)*fracS #immune loss back to N + + dP_acc_A.dt = (SU*SU2AU+SD*SD2AD)*fracS+ #Symptomatic move to Asymptomatic + AU*(Bu*(1-rAU/capacity)*(1-infA)+rAU*muWU) + + AD*(Bd*(1-rAD/capacity)*(1-infA)+rAD*muRD)- #total number of new infections + (att+ImmLost)*P_acc_A- # normal death + (AU*AU2SU+AD*AD2SD)*fracA #immune loss from A + + a <- 365/(2*pi) + db.dt = bavgnull * seasonality / a *(1- dryWidth *cos(phase+t/a))*sin(phase+t/a-dryWidth*sin(phase+t/a)) + + return(list(c(dPW_NU.dt,dPW_ND.dt,dPW_SU.dt,dPW_SD.dt,dPW_AU.dt,dPW_AD.dt, + dPR_NU.dt,dPR_ND.dt,dPR_SU.dt,dPR_SD.dt,dPR_AU.dt,dPR_AD.dt, + dNU.dt,dND.dt,dSU.dt,dSD.dt,dAU.dt,dAD.dt, + dP_acc_N.dt, dP_acc_S.dt, dP_acc_A.dt, db.dt))) + }) +} + +SEAI_wildOnly<-function(t,y,p){ + + with(as.list(c(y,p)),{ + # total host population size + N = NU+ND+SU+SD+AU+AD + # total parasite population size + #PW = PW_NU+PW_ND+PW_SU+PW_SD+PW_AU+PW_AD + #PR = PR_NU+PR_ND+PR_SU+PR_SD+PR_AU+PR_AD + #P = PW+PR + # parasite/host ratio + rNU <- (PW_NU+PR_NU)/(NU+1e-6) + rND <- (PW_ND+PR_ND)/(ND+1e-6) + rSU <- (PW_SU+PR_SU)/(SU+1e-6) + rSD <- (PW_SD+PR_SD)/(SD+1e-6) + rAU <- (PW_AU+PR_AU)/(AU+1e-6) + rAD <- (PW_AD+PW_AD)/(AD+1e-6) + + # prevalence + I_NU = 1-exp(-rNU) + I_ND = 1-exp(-rND) + I_SU = 1-exp(-rSU) + I_SD = 1-exp(-rSD) + I_AU = 1-exp(-rAU) + I_AD = 1-exp(-rAD) + + # proportion of hosts that have no parasites from W or + p0_NU <- c(exp(-rNU*PW_NU/(PW_NU+PR_NU+1e-6)), exp(-rNU*PR_NU/(PW_NU+PR_NU+1e-6))) + p0_ND <- c(exp(-rND*PW_ND/(PW_ND+PR_ND+1e-6)), exp(-rND*PR_ND/(PW_ND+PR_ND+1e-6))) + p0_SU <- c(exp(-rSU*PW_SU/(PW_SU+PR_SU+1e-6)), exp(-rSU*PR_SU/(PW_SU+PR_SU+1e-6))) + p0_SD <- c(exp(-rSD*PW_SD/(PW_SD+PR_SD+1e-6)), exp(-rSD*PR_SD/(PW_SD+PR_SD+1e-6))) + p0_AU <- c(exp(-rAU*PW_AU/(PW_AU+PR_AU+1e-6)), exp(-rAU*PR_AU/(PW_AU+PR_AU+1e-6))) + p0_AD <- c(exp(-rAD*PW_AD/(PW_AD+PR_AD+1e-6)), exp(-rAD*PR_AD/(PW_AD+PR_AD+1e-6))) + + # contributions of wild strain clones, wild strain in mixed, resistant clone and resistant mix in a bite + ctr_NU <- c(exp(-rNU)*(1/p0_NU[1]-1),(1-p0_NU[1])*(1-exp(-rNU)/p0_NU[1]),exp(-rNU)*(1/p0_NU[2]-1),(1-p0_NU[2])*(1-exp(-rNU)/p0_NU[2])) + ctr_ND <- c(exp(-rND)*(1/p0_ND[1]-1),(1-p0_ND[1])*(1-exp(-rND)/p0_ND[1]),exp(-rND)*(1/p0_ND[2]-1),(1-p0_ND[2])*(1-exp(-rND)/p0_ND[2])) + ctr_SU <- c(exp(-rSU)*(1/p0_SU[1]-1),(1-p0_SU[1])*(1-exp(-rSU)/p0_SU[1]),exp(-rSU)*(1/p0_SU[2]-1),(1-p0_SU[2])*(1-exp(-rSU)/p0_SU[2])) + ctr_SD <- c(exp(-rSD)*(1/p0_SD[1]-1),(1-p0_SD[1])*(1-exp(-rSD)/p0_SD[1]),exp(-rSD)*(1/p0_SD[2]-1),(1-p0_SD[2])*(1-exp(-rSD)/p0_SD[2])) + ctr_AU <- c(exp(-rAU)*(1/p0_AU[1]-1),(1-p0_AU[1])*(1-exp(-rAU)/p0_AU[1]),exp(-rAU)*(1/p0_AU[2]-1),(1-p0_AU[2])*(1-exp(-rAU)/p0_AU[2])) + ctr_AD <- c(exp(-rAD)*(1/p0_AD[1]-1),(1-p0_AD[1])*(1-exp(-rAD)/p0_AD[1]),exp(-rAD)*(1/p0_AD[2]-1),(1-p0_AD[2])*(1-exp(-rAD)/p0_AD[2])) + + # converted contribution of W or R with mixed infection cos---- + h_NU = c(ctr_NU[1]+ctr_NU[2]+ctr_NU[4]*(mixCost), ctr_NU[3]*(1-cloneCost)+ctr_NU[4]*(1-mixCost)) + h_ND = c(ctr_ND[1]+ctr_ND[2]+ctr_ND[4]*(mixCost), ctr_ND[3]*(1-cloneCost)+ctr_ND[4]*(1-mixCost)) + h_SU = c(ctr_SU[1]+ctr_SU[2]+ctr_SU[4]*(mixCost), ctr_SU[3]*(1-cloneCost)+ctr_SU[4]*(1-mixCost)) + h_SD = c(ctr_SD[1]+ctr_SD[2]+ctr_SD[4]*(mixCost), ctr_SD[3]*(1-cloneCost)+ctr_SD[4]*(1-mixCost)) + h_AU = c(ctr_AU[1]+ctr_AU[2]+ctr_AU[4]*(mixCost), ctr_AU[3]*(1-cloneCost)+ctr_AU[4]*(1-mixCost)) + h_AD = c(ctr_AD[1]+ctr_AD[2]+ctr_AD[4]*(mixCost), ctr_AD[3]*(1-cloneCost)+ctr_AD[4]*(1-mixCost)) + + #transmissibility is reduced to the number of infected hosts, + #receiving hosts needs to have open "resource room" for accepting new strains + B_PW = b*( + h_NU[1]*NU + + h_ND[1]*ND + + h_SU[1]*SU + + h_SD[1]*SD + + h_AU[1]*AU + + h_AD[1]*AD + )/N + + + B_PR = b*( + h_NU[2]*NU+ + h_ND[2]*ND+ + h_SU[2]*SU+ + h_SD[2]*SD+ + h_AU[2]*AU+ + h_AD[2]*AD + )/N + + + + # per capita biting rate for hosts who are not treated + Bu = (B_PW+B_PR) + # per capita biting rate for hosts who are drug treated + Bd = B_PR + #print(B) + + # pop size +1 is to prevent N = 0 for undefined scenario + fracN = P_acc_N/(NU+ND+1e-6) + fracS = P_acc_S/(SU+SD+1e-6) + fracA = P_acc_A/(AU+AD+1e-6) + + # probability that the infected strain has not been seen by the adaptive immune system + infN = (1-1/nstrains)^fracN + infS = (1-1/nstrains)^fracS + infA = (1-1/nstrains)^fracA + + + #naive class getting infected, and treated + NU2ND = (Bu*(1-rNU/capacity)*infN*d1) + + #naive U class getting enough # of infections to move to SU + NU2SU = (Bu*(1-rNU/capacity)*rho1*(1-infN))+rNU*muWU*rho1 + + #naive U class die from infections + NUInfDie = rNU*muWU*muNU + + #naive D class getting enough # of infections to move to SD + ND2SD = (Bd*(1-rND/capacity)*rho1*(1-infN)) + rND*rho1*muRD + + #naive D class die from infections + NDInfDie = rND*muRD*muND + + #SU class getting infected, show symptoms, and treated + SU2SD = (Bu*(1-rSU/capacity)*infS*d2) + + #SU class getting enough # of infections to move to AU + SU2AU = Bu*(1-rSU/capacity)*rho2*(1-infS) + rSU*rho2*muWU + + #SD class getting enough # of new infections to move to AD + SD2AD = (Bd*(1-rSD/capacity)*rho2*(1-infS)) + rSD*rho2*muRD + + #AU class getting infected, show symptoms, and treated + AU2AD = (Bu*(1-rAU/capacity)*infA*omega*d3) + + #lose immunity----- + #SU back to NU due to loss of immune memory + hsu = (Bu*(1-rSU/capacity)) + SU2SD+SU2AU+att + SU2NU = hsu*exp(-hsu/ImmLost)/(1-exp(-hsu/ImmLost)) + + #SD back to ND due to loss of immune memory + hsd = (Bd*(1-rSD/capacity)) +1/Tau+att + SD2ND = hsd*exp(-hsd/ImmLost)/(1-exp(-hsd/ImmLost)) + + #AU back to SU due to loss of immune memory + hau = (Bu*(1-rAU/capacity)) + AU2AD + att + AU2SU = hau*exp(-hau/ImmLost)/(1-exp(-hau/ImmLost)) + + #AD back to SD due to loss of immune memory + had = (Bd*(1-rAD/capacity)) + 1/Tau + att + AD2SD = had*exp(-had/ImmLost)/(1-exp(-had/ImmLost)) + + # Parasite pop ODE------ + ## sensitive------- + dPW_NU.dt = B_PW*NU*infN*(1-rNU/capacity) + #new infections + PW_SU*SU2NU + # SU lose immunity back to NU + (PW_ND/Tau)- # drug loose effectiveness + (PW_NU*NU2ND) - #naive class getting infected, and treated + (PW_NU*NU2SU) - #naive class getting enough # of infections to move to S + (PW_NU*NUInfDie)- #naive class die from infections + (PW_NU*att)- #normal death rate + (PW_NU*muWU)#clearance of infection + + + #print(dNU.dt) + + dPW_ND.dt = B_PW*ND*infN*(1-rND/capacity) + #new infections + PW_SD*SD2ND + # SD lose immunity back to ND + (PW_NU*NU2ND) - #naive class getting infected, and treated + (PW_ND/Tau) - # drug loose effectiveness + (PW_ND*ND2SD) -#naive class getting enough # of infections to move to S + (PW_ND*NDInfDie) -#naive class die from infections + (PW_ND*att)- #normal death rate + (PW_ND*muWD)#clearance from drug + + #print(dND.dt) + + dPW_SU.dt = B_PW*SU*infS*(1-rSU/capacity) + #new infections + (PW_NU*NU2SU) +#naive class getting enough # of infections to move to S + (PW_AU*AU2SU) + #AU moves back to SU due to immunity loss + (PW_SD/Tau)- # drug loose effectiveness + (PW_SU*SU2SD)- #symptomatic class getting infected, show symptoms, and treated + (PW_SU*SU2AU) -#symptomatic class getting enough # of infections to move to AU + (PW_SU*SU2NU) - # lose immunity back to NU + (PW_SU*att)- #normal death rate + (PW_SU*muWU)#clearance of infection + + dPW_SD.dt = B_PW*SD*infS*(1-rSD/capacity) + #new infections + (PW_ND*ND2SD)+ #naive class getting enough # of infections to move to S + (PW_AD*AD2SD) + #AD moves back to SU due to immunity loss + (PW_SU*SU2SD)- #symptomatic class getting infected, show symptoms, and treated + (PW_SD/Tau) - # drug loose effectiveness + (PW_SD*SD2AD)- #symptomatic class getting enough # of infections to move to AD + (PW_SD*SD2ND) - # lose immunity back to ND + (PW_SD*att)- #normal death rate + (PW_SD*muWD)#clearance from drug + + dPW_AU.dt = B_PW*AU*infA*(1-rAU/capacity) + #new infections + (PW_SU*SU2AU)+ #symptomatic class getting enough # of infections to move to AU + (PW_AD/Tau)- # drug loose effectiveness + (PW_AU*AU2AD)- #asymptomatic class getting infected, show symptoms, and treated + (PW_AU*att)- #normal death rate + (PW_AU*AU2SU) - #AU moves back to SU due to immunity loss + (PW_AU*muWU)#clearance from infection + + dPW_AD.dt = B_PW*AD*infA*(1-rAD/capacity) + #new infections + (PW_SD*SD2AD) + #symptomatic class getting enough # of infections to move to AD + (PW_AU*AU2AD)- #asymptomatic class getting infected, show symptoms, and treated + (PW_AD/Tau)- # drug loose effectiveness + (PW_AD*att)- #normal death rate + (PW_AD*AD2SD) - #AD moves back to SU due to immunity loss + (PW_AD*muWD)#clearance from drug + + ## resistant------- + dPR_NU.dt = 0 + + #print(dNU.dt) + + dPR_ND.dt = 0 + + #print(dND.dt) + + dPR_SU.dt = 0 + + dPR_SD.dt = 0 + + dPR_AU.dt = 0 + + dPR_AD.dt = 0 + + # Generalized immunity ODE------ + dNU.dt = birth + + SU*SU2NU + # lose immunity + (ND/Tau)- # drug loose effectiveness + NU*NU2ND - #naive class getting infected, and treated + NU*NU2SU - #naive class getting enough # of infections to move to S + NU*NUInfDie- #naive class die from infections + (NU*att)#normal death rate + + + #print(dNU.dt) + + dND.dt = NU*NU2ND + #naive class getting infected, and treated + SD*SD2ND - # lose immunity + (ND/Tau) - # drug loose effectiveness + ND*ND2SD -#naive class getting enough # of infections to move to S + ND*NDInfDie -#naive class die from infections + (ND*att) #normal death rate + #print(dND.dt) + + dSU.dt = NU*NU2SU +#naive class getting enough # of infections to move to S + (AU*AU2SU) + #AU moves back to SU due to immunity loss + (SD/Tau)- # drug loose effectiveness + SU*SU2SD- #symptomatic class getting infected, show symptoms, and treated + SU*SU2AU -#symptomatic class getting enough # of infections to move to AU + SU*SU2NU - # lose immunity + (SU*att) #normal death rate + + dSD.dt = ND*ND2SD+ #naive class getting enough # of infections to move to S + (AD*AD2SD) + #AD moves back to SD due to immunity loss + SU*SU2SD- #symptomatic class getting infected, show symptoms, and treated + (SD/Tau) - # drug loose effectiveness + SD*SD2AD- #symptomatic class getting enough # of infections to move to AD + SD*SD2ND - # lose immunity + (SD*att) #normal death rate + + dAU.dt = SU*SU2AU+ #symptomatic class getting enough # of infections to move to AS + (AD/Tau)- # drug loose effectiveness + AU*AU2AD- #asymptomatic class getting infected, show symptoms, and treated + (AU*AU2SU) - #AU moves back to SU due to immunity loss + (AU*att) #normal death rate + + dAD.dt = SD*SD2AD + #symptomatic class getting enough # of infections to move to AS + AU*AU2AD- #asymptomatic class getting infected, show symptoms, and treated + (AD/Tau)- # drug loose effectiveness + (AD*AD2SD) - #AD moves back to SD due to immunity loss + (AD*att) #normal death rate + + #sprintf("%.0f, %.0f,%.0f,%.0f,%.0f,%.0f",dNU.dt,dND.dt,dSU.dt,dSD.dt,dAU.dt,dAD.dt) + + # track the mean number of times infected per immunity class------ + dP_acc_N.dt = NU*NU2SU/rho1 + ND*ND2SD/rho1- # total number of infections received + (NU*(NUInfDie))*fracN- #when naive U class die how many infections deducted + (ND*(NDInfDie))*fracN- #when naive D class die many infections deducted + (NU*NU2SU+ND*ND2SD)*fracN- #when naive class leave to S + (att+ImmLost)*P_acc_N+ + (SU*SU2NU+SD*SD2ND)*fracS #immune loss back to N + + dP_acc_S.dt = (NU*NU2SU+ND*ND2SD)*fracN+ #when naive class leave to S + SU*SU2AU/rho2 + + SD*SD2AD/rho2 + #total number of new infections + (AU*AU2SU+AD*AD2SD)*fracA- #immune loss from A + (att+ImmLost)*P_acc_S- # normal death+immune loss + (SU*SU2AU+SD*SD2AD)*fracS- #Symptomatic move to Asymptomatic + (SU*SU2NU+SD*SD2ND)*fracS #immune loss back to N + + dP_acc_A.dt = (SU*SU2AU+SD*SD2AD)*fracS+ #Symptomatic move to Asymptomatic + AU*(Bu*(1-rAU/capacity)*(1-infA)+rAU*muWU) + + AD*(Bd*(1-rAD/capacity)*(1-infA)+rAD*muRD)- #total number of new infections + (att+ImmLost)*P_acc_A- # normal death + (AU*AU2SU+AD*AD2SD)*fracA #immune loss from A + + a <- 365/(2*pi) + db.dt = bavgnull * seasonality / a *(1- dryWidth *cos(phase+t/a))*sin(phase+t/a-dryWidth*sin(phase+t/a)) + + return(list(c(dPW_NU.dt,dPW_ND.dt,dPW_SU.dt,dPW_SD.dt,dPW_AU.dt,dPW_AD.dt, + dPR_NU.dt,dPR_ND.dt,dPR_SU.dt,dPR_SD.dt,dPR_AU.dt,dPR_AD.dt, + dNU.dt,dND.dt,dSU.dt,dSD.dt,dAU.dt,dAD.dt, + dP_acc_N.dt, dP_acc_S.dt, dP_acc_A.dt, db.dt))) + }) +} + +allPara<-read.csv(paramFile,sep=",",header=T) + +currentPara<-allPara[allPara$No==No,] + +# Step 1 get no drug treating intensity, wildOnly----- + +currentPara$d1<-0 +currentPara$d2<-0 +currentPara$d3<-0 + +t2 = seq(from=0,to=30*365,by=1) +N0 = c(PW_NU=100,PW_ND=0,PW_SU=0,PW_SD=0,PW_AU=0,PW_AD=0, + PR_NU=0,PR_ND=0,PR_SU=0,PR_SD=0,PR_AU=0,PR_AD=0, + NU=10000,ND=0,SU=0,SD=0,AU=0,AD=0, + P_acc_N=0,P_acc_S=0,P_acc_A=0, + b=currentPara$bavgnull*(1-currentPara$seasonality)) +print(N0) +out2 = ode(y=N0,times=t2,func=SEAI_wildOnly,parms=currentPara) + +out2<-as_tibble(out2) +sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +print(tail(sumOut2)) + +print(abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)) +print(abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)) + +while((abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)>0.001 )| + (abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)>0.001)){ + print(out2[30*365,2:23]) + t2<-t2+30*365 + N0 = as.numeric(out2[30*365+1,2:23]) + names(N0)<-colnames(out2[,2:23]) + out2 = ode(y=N0,times=t2,func=SEAI_wildOnly,parms=currentPara) + out2<-as_tibble(out2) + sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +} +out2<-as.data.frame(out2) +out2<-out2%>%mutate(m_N = P_acc_N/(NU+ND),m_S =P_acc_S/(SU+SD), m_A = P_acc_A/(AU+AD), + PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD, + P=PW+PR,N = NU+ND+SU+SD+AU+AD, prev = 1-exp(-P/N)) + +##you can check the output through this graph +#out2.melt<-reshape2::melt(out2%>%filter(time%%10==0,time>1000), id.vars=1) +#ggplot(out2.melt, aes(time,value ))+geom_line()+ylim(0,NA)+ +# facet_wrap(.~variable,scales="free_y") +outData<-as.data.frame(cbind(jobid=jobid,wildOnly=1,currentPara,tail(out2,1))) +if(No!=1){ + write.table(outData, + file = outFile, row.names=F, col.names=F,sep=",", + quote=F,append=T) +}else{ + write.csv(outData, + file = outFile, row.names=F, + quote=F) + +} + +storeOut<-tail(out2,1)[,2:23] +# Step 2 treat occasionally, wildOnly----- + +currentPara$d1<-0.5 +currentPara$d2<-0.5 +currentPara$d3<-0.5 + +t2 = seq(from=0,to=30*365,by=1) +N0 = c(PW_NU=100,PW_ND=0,PW_SU=0,PW_SD=0,PW_AU=0,PW_AD=0, + PR_NU=0,PR_ND=0,PR_SU=0,PR_SD=0,PR_AU=0,PR_AD=0, + NU=10000,ND=0,SU=0,SD=0,AU=0,AD=0, + P_acc_N=0,P_acc_S=0,P_acc_A=0, + b=currentPara$bavgnull*(1-currentPara$seasonality)) +print(N0) +out2 = ode(y=N0,times=t2,func=SEAI_wildOnly,parms=currentPara) + +out2<-as_tibble(out2) +sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +print(tail(sumOut2)) + +print(abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)) +print(abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)) + +while((abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)>0.001 )| + (abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)>0.001)){ + print(out2[30*365,2:23]) + t2<-t2+30*365 + N0 = as.numeric(out2[30*365+1,2:23]) + names(N0)<-colnames(out2[,2:23]) + out2 = ode(y=N0,times=t2,func=SEAI_wildOnly,parms=currentPara) + out2<-as_tibble(out2) + sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +} +out2<-as.data.frame(out2) +out2<-out2%>%mutate(m_N = P_acc_N/(NU+ND),m_S =P_acc_S/(SU+SD), m_A = P_acc_A/(AU+AD), + PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD, + P=PW+PR,N = NU+ND+SU+SD+AU+AD, prev = 1-exp(-P/N)) + +##you can check the output through this graph +#out2.melt<-reshape2::melt(out2%>%filter(time%%10==0,time>10), id.vars=1) +#ggplot(out2.melt, aes(time,value ))+geom_line()+ylim(0,NA)+ +# facet_wrap(.~variable,scales="free_y") +outData<-as.data.frame(cbind(jobid=jobid,wildOnly=1,currentPara,tail(out2,1))) +#if(file.exists(outFile)){ +write.table(outData, + file = outFile, row.names=F, col.names=F,sep=",", + quote=F,append=T) +#}else{ +# write.csv(outData, +# file = outFile, row.names=F, +# quote=F) +# +#} + +storeOut<-rbind(storeOut,tail(out2,1)[,2:23]) +# Step 3 full treatment, wildOnly----- + +currentPara$d1<-1 +currentPara$d2<-1 +currentPara$d3<-1 + +t2 = seq(from=0,to=30*365,by=1) +N0 = c(PW_NU=100,PW_ND=0,PW_SU=0,PW_SD=0,PW_AU=0,PW_AD=0, + PR_NU=0,PR_ND=0,PR_SU=0,PR_SD=0,PR_AU=0,PR_AD=0, + NU=10000,ND=0,SU=0,SD=0,AU=0,AD=0, + P_acc_N=0,P_acc_S=0,P_acc_A=0, + b=currentPara$bavgnull*(1-currentPara$seasonality)) +print(N0) +out2 = ode(y=N0,times=t2,func=SEAI_wildOnly,parms=currentPara) + +out2<-as_tibble(out2) +sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +print(tail(sumOut2)) + +print(abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)) +print(abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)) + +while((abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)>0.001 )| + (abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)>0.001)){ + print(out2[30*365,2:23]) + t2<-t2+30*365 + N0 = as.numeric(out2[30*365+1,2:23]) + names(N0)<-colnames(out2[,2:23]) + out2 = ode(y=N0,times=t2,func=SEAI_wildOnly,parms=currentPara) + out2<-as_tibble(out2) + sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +} +out2<-as.data.frame(out2) +out2<-out2%>%mutate(m_N = P_acc_N/(NU+ND),m_S =P_acc_S/(SU+SD), m_A = P_acc_A/(AU+AD), + PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD, + P=PW+PR,N = NU+ND+SU+SD+AU+AD, prev = 1-exp(-P/N)) + +##you can check the output through this graph +#out2.melt<-reshape2::melt(out2%>%filter(time%%10==0,time>10), id.vars=1) +#ggplot(out2.melt, aes(time,value ))+geom_line()+ylim(0,NA)+ +# facet_wrap(.~variable,scales="free_y") +outData<-as.data.frame(cbind(jobid=jobid,wildOnly=1,currentPara,tail(out2,1))) +#if(file.exists(outFile)){ +write.table(outData, + file = outFile, row.names=F, col.names=F,sep=",", + quote=F,append=T) +#}else{ +# write.csv(outData, +# file = outFile, row.names=F, +# quote=F) +# +#} + +storeOut<-rbind(storeOut,tail(out2,1)[,2:23]) + +# Step 4 resistant strains only, no treatment ------ +currentPara$d1<-0 +currentPara$d2<-0 +currentPara$d3<-0 + +t2 = seq(from=0,to=30*365,by=1) +N0 = c(PW_NU=0,PW_ND=0,PW_SU=0,PW_SD=0,PW_AU=0,PW_AD=0, + PR_NU=100,PR_ND=0,PR_SU=0,PR_SD=0,PR_AU=0,PR_AD=0, + NU=10000,ND=0,SU=0,SD=0,AU=0,AD=0, + P_acc_N=0,P_acc_S=0,P_acc_A=0, + b=currentPara$bavgnull*(1-currentPara$seasonality)) +print(N0) +out2 = ode(y=N0,times=t2,func=SEAI_resOnly,parms=currentPara) + +out2<-as_tibble(out2) +sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +print(tail(sumOut2)) + +print(abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)) +print(abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)) + +while((abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)>0.001 )| + (abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)>0.001)){ + print(out2[30*365,2:23]) + t2<-t2+30*365 + N0 = as.numeric(out2[30*365+1,2:23]) + names(N0)<-colnames(out2[,2:23]) + out2 = ode(y=N0,times=t2,func=SEAI_resOnly,parms=currentPara) + out2<-as_tibble(out2) + sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(P),meanN=mean(N)) +} +out2<-as.data.frame(out2) +out2<-out2%>%mutate(m_N = P_acc_N/(NU+ND),m_S =P_acc_S/(SU+SD), m_A = P_acc_A/(AU+AD), + PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD, + P=PW+PR,N = NU+ND+SU+SD+AU+AD, prev = 1-exp(-P/N)) + +##you can check the output through this graph +#out2.melt<-reshape2::melt(out2%>%filter(time%%10==0,time>10), id.vars=1) +#ggplot(out2.melt, aes(time,value ))+geom_line()+ylim(0,NA)+ +# facet_wrap(.~variable,scales="free_y") +outData<-as.data.frame(cbind(jobid=jobid,wildOnly=0,currentPara,tail(out2,1))) +#if(file.exists(outFile)){ +write.table(outData, + file = outFile, row.names=F, col.names=F,sep=",", + quote=F,append=T) +#}else{ +# write.csv(outData, +# file = outFile, row.names=F, +# quote=F) +# +#} + +# Step 5 treat occasionally, wildOnly + resistant----- + +currentPara$d1<-0.5 +currentPara$d2<-0.5 +currentPara$d3<-0.5 + +t2 = seq(from=0,to=30*365,by=1) +N0 = unlist(storeOut[2,]) + +N0["PR_NU"]<-10 +N0["PR_ND"]<-10 +N0["PR_SU"]<-10 +N0["PR_SD"]<-10 +N0["PR_AU"]<-10 +N0["PR_AD"]<-10 +print(N0) +out2 = ode(y=N0,times=t2,func=SEAI_p,parms=currentPara) + +out2<-as_tibble(out2) +sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(PR),meanN=mean(N)) +print(tail(sumOut2)) + +print(abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)) +print(abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)) + +while((abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)>0.001 )| + (abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)>0.001)){ + print(out2[30*365,2:23]) + t2<-t2+30*365 + N0 = as.numeric(out2[30*365+1,2:23]) + names(N0)<-colnames(out2[,2:23]) + out2 = ode(y=N0,times=t2,func=SEAI_p,parms=currentPara) + out2<-as_tibble(out2) + sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(PR),meanN=mean(N)) +} +out2<-as.data.frame(out2) +out2<-out2%>%mutate(m_N = P_acc_N/(NU+ND),m_S =P_acc_S/(SU+SD), m_A = P_acc_A/(AU+AD), + PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD, + P=PW+PR,N = NU+ND+SU+SD+AU+AD, prev = 1-exp(-P/N)) + +##you can check the output through this graph +#out2.melt<-reshape2::melt(out2%>%filter(time%%10==0,time>10), id.vars=1) +#ggplot(out2.melt, aes(time,value ))+geom_line()+ylim(0,NA)+ +# facet_wrap(.~variable,scales="free_y") +outData<-as.data.frame(cbind(jobid=jobid,wildOnly=0,currentPara,tail(out2,1))) +#if(file.exists(outFile)){ +write.table(outData, + file = outFile, row.names=F, col.names=F,sep=",", + quote=F,append=T) +#}else{ +# write.csv(outData, +# file = outFile, row.names=F, +# quote=F) +# +#} + +# Step 6 treat fully, wildOnly + resistant----- + +currentPara$d1<-1 +currentPara$d2<-1 +currentPara$d3<-1 + +t2 = seq(from=0,to=30*365,by=1) +N0 = unlist(storeOut[3,]) +N0["PR_NU"]<-10 +N0["PR_ND"]<-10 +N0["PR_SU"]<-10 +N0["PR_SD"]<-10 +N0["PR_AU"]<-10 +N0["PR_AD"]<-10 +print(N0) +out2 = ode(y=N0,times=t2,func=SEAI_p,parms=currentPara) + +out2<-as_tibble(out2) +sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(PR),meanN=mean(N)) +print(tail(sumOut2)) + +print(abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)) +print(abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)) + +while((abs(sumOut2[20,"meanP"]-sumOut2[30,"meanP"])/(sumOut2[30,"meanP"]+0.0001)>0.001 )| + (abs(sumOut2[20,"meanN"]-sumOut2[30,"meanN"])/(sumOut2[30,"meanN"]+0.0001)>0.001)){ + print(out2[30*365,2:23]) + t2<-t2+30*365 + N0 = as.numeric(out2[30*365+1,2:23]) + names(N0)<-colnames(out2[,2:23]) + out2 = ode(y=N0,times=t2,func=SEAI_p,parms=currentPara) + out2<-as_tibble(out2) + sumOut2<-out2%>%mutate(year = floor(time/365),PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD,P=PW+PR, N = NU+ND+SU+SD+AU+AD)%>% + group_by(year)%>%summarise(meanP=mean(PR),meanN=mean(N)) +} +out2<-as.data.frame(out2) +out2<-out2%>%mutate(m_N = P_acc_N/(NU+ND),m_S =P_acc_S/(SU+SD), m_A = P_acc_A/(AU+AD), + PW = PW_NU+PW_SU+PW_AU+PW_ND+PW_SD+PW_AD, + PR = PR_NU+PR_SU+PR_AU+PR_ND+PR_SD+PR_AD, + P=PW+PR,N = NU+ND+SU+SD+AU+AD, prev = 1-exp(-P/N)) + +##you can check the output through this graph +#out2.melt<-reshape2::melt(out2%>%filter(time%%10==0,time>10), id.vars=1) +#ggplot(out2.melt, aes(time,value ))+geom_line()+ylim(0,NA)+ +# facet_wrap(.~variable,scales="free_y") +outData<-as.data.frame(cbind(jobid=jobid,wildOnly=0,currentPara,tail(out2,1))) +#if(file.exists(outFile)){ +write.table(outData, + file = outFile, row.names=F, col.names=F,sep=",", + quote=F,append=T) +#}else{ +# 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