diff --git a/ODESImmunity2-copy.R b/ODESImmunity2-copy.R new file mode 100644 index 0000000..9f35222 --- /dev/null +++ b/ODESImmunity2-copy.R @@ -0,0 +1,521 @@ +require(deSolve) +#library(tidyverse) +SEAI<-function(t,y,p){ + PSU = y[1] + PSD = y[2] + #PS = y[3] + PRU = y[3] + PRD = y[4] + #PR = y[6] + NU = y[5] + ND = y[6] + SU = y[7] + SD = y[8] + AU = y[9] + AD = y[10] + beta = y[11] + #PMOR = y[12] + #HMOR = y[13] + #PSUACC = y[12] + #PSDACC = y[13] + #PRUACC = y[14] + #PRDACC = y[15] + #NUACC = y[18] + #NDACC = y[19] + PSUACCN2 = y[12] + PSDACCN2= y[13] + PRUACCN2 = y[14] + PRDACCN2 = y[15] + #PSUACC210 = y[16] + #PSDACC210 = y[17] + #PRUACC210 = y[18] + #PRDACC210 = y[19] + #ACC210U = y[20] + #ACC210D = y[21] + #ACC210NU = y[22] + #ACC210ND = y[23] + #PSUACCN2 = y[24] + #PSDACCN2 = y[25] + #PRUACCN2 = y[26] + #PRDACCN2 = y[27] + PSUACC = y[16] + PSDACC = y[17] + PRUACC = y[18] + PRDACC = y[19] + PSUACCA = y[20] + PSDACCA = y[21] + PRUACCA = y[22] + PRDACCA = y[23] + with(as.list(p),{ + N = y[5]+y[6]+y[7]+y[8]+y[9]+y[10] + m = (PSU+PSD+PRU+PRD)/N + I = 1-exp(-m)#(1-((PSU+PSD+PRU+PRD)/(N*K))) 1-exp(-m) + #pone = 1 - (m/K) + #ptwo = m/(K-1) + #pthree = m/(K-2) + #pfour = m/(K-3) + #pfive = m/(K-4) + #psix = m/(K-5) + #pseven = m/(K-6) + #peight = m/(K-7) + #pnine = m/(K-8) + #pten = m/(K-9) + ##I = pnbinom(K,size=K,prob=p) - pnbinom(0,size=K,prob=p) + #I = pnbinom(K,size=K,prob=pone) + pnbinom(K-1,size=K,prob=pone) + pnbinom(K-2,size=K,prob=pone) + pnbinom(K-3,size=K,prob=pone) + pnbinom(K-4,size=K,prob=pone) + pnbinom(K-5,size=K,prob=pone)+ pnbinom(K-6,size=K,prob=pone)+ pnbinom(K-7,size=K,prob=pone)+ pnbinom(K-8,size=K,prob=pone)+pnbinom(K-9,size=K,prob=pone) - pnbinom(0,size=K,prob=pone) - pnbinom(0,size=K-1,prob=ptwo) - pnbinom(0,size=K-2,prob=pthree) - pnbinom(0,size=K-3,prob=pfour) - pnbinom(0,size=K-4,prob=pfive) - pnbinom(0,size=K-5,prob=psix)- pnbinom(0,size=K-6,prob=pseven)- pnbinom(0,size=K-7,prob=peight)- pnbinom(0,size=K-8,prob=pnine)#-pnbinom(0,size=K-9,prob=pten) + #I = dnbinom(K,size=1,prob=pone) + kap = -1 + a =365/(2*pi) + ps = 0 + b = abs(beta) + S = 1-wr + k=12 + h = 1-(S/(1+0.1*exp(-k*(I-1)))) + # rho_inverse = vector(mode="numeric",length=nstrains) + # for (i in 1:nstrains){ + # rho_inverse[i] = 1/i + # } + #n_infections = nstrains*sum(rho_inverse) + #prob_infection = nstrains/n_infections + #prob_asymptomatic = 1/n_infections + #rho3=prob_asymptomatic + #rho4=rho3 + #h=wr + #totalm = (PSUACC+PSDACC+PRUACC+PRDACC)/(K*(SU+SD)) + frac1 = (PSUACC+PRUACC)/(SU) + frac2 = (PSDACC+PRDACC)/(SD) + frac3 = (PSUACCA+PRUACCA)/AU + frac4 = (PSDACCA+PRDACCA)/AD + #frac2 = PSDACC/(SD) + #frac3 = PRUACC/(SU) + #frac4 = PRDACC/(SD) + #f1 = frac1 #*(1-rho3) + #f2 = frac2 #* + #f3 = frac3 + #f4 = frac4 + #totalm = m + prob23 = min(frac1,nstrains)/nstrains + prob24 = min(frac2,nstrains)/nstrains + rhobin1 = dbinom(nstrains,size=nstrains,prob=prob23*0.999999) + rhobin2 = dbinom(nstrains,size=nstrains,prob=prob24*0.999999) + ratr = ((PRU+PRD)*h)/(PSU+PSD+((PRU+PRD)*h)) + #rats = (PSU+PSD)/(PSU+PSD+PRU+PRD) + #eps = (PSD+PSU+((PRD+PRU)*(wr)))/N + #Ndeaths_demo = del*att*NU*t+del*att*ND*t + #Sdeaths = del*att*SU*t+del*att*SD*t + #Adeaths = (del*att*AU*t)+(del*att*AD*t) + #totalAhosts = AU+AD#+(del*att*AU*t)+(del*att*AD*t) + #rebirth = (PMOR)/(SU+SD) + #probbin = ((PSUACC+PSDACC+PRUACC+PRDACC))/((K)*(SU+SD)) + #mbin = pnbinom((1/rho3),size = 1,prob=probbin,lower.tail=TRUE) + #meanbin = 1*(1-probbin)/probbin #mean number of treatment failures before a successful immune defense + #meanstrainsS = meanbin*((1-rho3)^meanbin) + meanstrainsS1 = (1-rho3)^(frac1) + meanstrainsS2 = (1-rho3)^(frac2) + meanstrainsS3 = (1-rho3)^(frac1) + meanstrainsS4 = (1-rho3)^(frac2) + meanstrainsS5 = (1-rho3)^(frac3) + meanstrainsS6 = (1-rho3)^(frac4) + eps = (PSD+PSU+((PRD+PRU)*(h)))/(PSD+PSU+PRD+PRU) + #dPSU.dt = - (b*(PSU/N)*ws*(NU+SU*(1-f1)*meanstrainsS1+AU*omega1)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(NU+SU*(1-f1)*meanstrainsS1+AU*omega1)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (muSU)*(PSU)#-(del*att*(1/N)*(NU+SU+AU)*PSU) + #dPSU.dt = - (b*(PSU/N)*ws*(NU+SU+AU*omega1)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(NU+SU+AU*omega1)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (muSU)*(PSU)#-(del*att*(1/N)*(NU+SU+AU)*PSU) + dPSU.dt = - (b*(PSU/N)*ws*(NU+SU*(meanstrainsS1+omega1)+AU*(omega1+meanstrainsS5))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(NU+SU*(meanstrainsS1+omega1)+AU*(omega1+meanstrainsS5))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (muSU)*(PSU)#-(del*att*(1/N)*(NU+SU+AU)*PSU) + #dPSD.dt = - (b*(PSU/N)*ws*(ND+SD*(1-f2)*meanstrainsS2+AD*0)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(ND+SD*(1-f2)*meanstrainsS2+AD*0)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (muSD)*(PSD)#-(del*att*(1/N)*(ND+SD+AD)*PSD) + #dPSD.dt = - (b*(PSU/N)*ws*(ND+SD+AD*omega1)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(ND+SD+AD*omega1)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (muSD)*(PSD)#-(del*att*(1/N)*(ND+SD+AD)*PSD) + dPSD.dt = - (b*(PSU/N)*ws*(ND+SD*(meanstrainsS2+omega1)+AD*(omega1+meanstrainsS6))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(ND+SD*(meanstrainsS2+omega1)+AD*(omega1+meanstrainsS6))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (muSD)*(PSD)#-(del*att*(1/N)*(ND+SD+AD)*PSD) + #dPRU.dt = - (b*(PRU/N)*h*(NU+SU+AU*omega1)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PRD/N)*h*(NU+SU+AU*omega1)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (muRU)*(PRU)#-(del*att*(1/N)*(NU+SU+AU)*PRU) + dPRU.dt = - (b*(PRU/N)*h*(NU+SU*(meanstrainsS3+omega1)+AU*(omega1+meanstrainsS5))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PRD/N)*h*(NU+SU*(meanstrainsS3+omega1)+AU*(omega1+meanstrainsS5))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (muRU)*(PRU)#-(del*att*(1/N)*(NU+SU+AU)*PRU) + #dPRD.dt = - (b*(PRU/N)*h*(ND+SD+AD*omega1)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PRD/N)*h*(ND+SD+AD*omega1)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (muRD)*(PRD)#-(del*att*(1/N)*(ND+SD+AD)*PRD) + dPRD.dt = - (b*(PRU/N)*h*(ND+SD*(meanstrainsS4+omega1)+AD*(omega1+meanstrainsS6))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PRD/N)*h*(ND+SD*(meanstrainsS4+omega1)+AD*(omega1+meanstrainsS6))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (muRD)*(PRD)#-(del*att*(1/N)*(ND+SD+AD)*PRD) + #dNU.dt = (del*(AU+AD))+(ND/Tau)-(b*I*eps*NU*(d+rho1))-(muNU*NU) - (del*att*NU) + dNU.dt = del+(ND/Tau)-(b*I*eps*NU*(d1+rho1))-(muNU*NU*I*b*eps) - (del*att*NU) + dND.dt = (b*I*eps*NU*d1)-(ND/Tau)-(ratr*b*I*eps*ND*rho2)-(muND*ratr*ND*I*b*eps) - (del*att*ND) + dSU.dt = (b*I*eps*NU*rho1)+(SD/Tau)-(b*I*eps*SU*(d2*(meanstrainsS1+omega1)+(eta))) - (del*att*SU) + dSD.dt = (ratr*b*I*eps*ND*rho2)+(b*I*eps*SU*d2*(meanstrainsS1+omega1))-(SD/Tau)-(ratr*b*I*eps*SD*eta) - (del*att*SD) + #dAU.dt = rat*(AU+AD)*(1-((AU+AD)/L))+(AD/Tau)+(b*I*eps*SU*rho3)-(b*I*eps*omega1*AU*d) - (del*att*AU) + dAU.dt = (AD/Tau)+(b*I*eps*SU*eta)-(b*I*eps*(omega1)*AU*d3) - (del*att*AU) + #dAD.dt = rat*(AU+AD)*(1-((AU+AD)/L))+(b*I*eps*SD*rho4)+(b*I*eps*omega1*AU*d)-(AD/Tau) - (del*att*AD) + dAD.dt = (ratr*b*I*eps*SD*eta)+(b*I*eps*(omega1)*AU*d3)-(AD/Tau) - (del*att*AD) + dbeta.dt = ((L*bavgnull*sin(((t/a)+ps)-kap*sin((t/a)+ps))*(kap*cos((t/a)+ps)-1))/a) + #dPMOR.dt = (muSU)*(PSUACC)+(muSD)*PSDACC+muRU*PRUACC+muRD*PRDACC + #dHMOR.dt = del*att*del*t+(muNU*NUACC*I*b*eps)+(muND*ratr*NDACC*I*b*eps) + #dPSUACC.dt = - (b*(PSU/N)*ws*(SU*meanstrainsS1)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(SU*meanstrainsS1)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K))+(b*I*eps*NU*rho1)*(PSUACCN2/NU)+(SD/Tau)*(PSDACC/SD)+(-(b*I*eps*SU*(d2+(rho3))) - (del*att*SU))*(PSUACC/SU)#*(1-rho3) + #dPSDACC.dt = - (b*(PSU/N)*ws*(SD*meanstrainsS2)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(SD*meanstrainsS2)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K))+(ratr*b*I*eps*ND*rho2)*(PSDACCN2/ND)+(b*I*eps*SU*d2)*(PSUACC/SU)+ (-(SD/Tau)-(ratr*b*I*eps*SD*rho4) - (del*att*SD))*(PSDACC/SD)- (muSD)*(PSDACC)#death rate included because of clearance by drugs rather than immune system + #dPRUACC.dt = - (b*(PRU/N)*h*(SU*meanstrainsS3)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PRD/N)*h*(SU*meanstrainsS3)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) + (b*I*eps*NU*rho1)*(PRUACCN2/NU)+(SD/Tau)*(PRDACC/SD)+(-(b*I*eps*SU*(d2+(rho3))) - (del*att*SU))*(PRUACC/SU)#*(1-rho3) + #dPRDACC.dt = - (b*(PRU/N)*h*(SD*meanstrainsS4)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PRD/N)*h*(SD*meanstrainsS4)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) + (ratr*b*I*eps*ND*rho2)*(PRDACCN2/ND)+(b*I*eps*SU*d2)*(PRUACC/SU)+ (-(SD/Tau)-(ratr*b*I*eps*SD*rho4) - (del*att*SD))*(PRDACC/SD)#*(1-rho4) + #dPSUACCN.dt = - (b*(PSU/N)*ws*(NU)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(NU)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K))+(ND/Tau)*(PSDACCN/ND)+(-(b*I*eps*NU*(d1+rho1))-(muNU*NU*I*b*eps) - (del*att*NU))*(PSUACCN/NU) - (muSU)*(PSUACCN)#*(1-rho3) + #dPSDACCN.dt = - (b*(PSU/N)*ws*(ND)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(ND)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) +(b*I*eps*NU*d1)*(PSUACCN/NU)+ (-(ND/Tau)-(ratr*b*I*eps*ND*rho2)-(muND*ratr*ND*I*b*eps) - (del*att*ND))*(PSDACCN/ND) - (muSD)*(PSDACCN)#*(1-rho4) + #dPRUACCN.dt = - (b*(PRU/N)*h*(NU)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PRD/N)*h*(NU)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) +(ND/Tau)*(PRDACCN/ND)+(-(b*I*eps*NU*(d1+rho1))-(muNU*NU*I*b*eps) - (del*att*NU))*(PRUACCN/NU) - (muRU)*(PRUACCN)#*(1-rho3) + #dPRDACCN.dt = - (b*(PRU/N)*h*(ND)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PRD/N)*h*(ND)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) + (b*I*eps*NU*d1)*(PRUACCN/NU)+ (-(ND/Tau)-(ratr*b*I*eps*ND*rho2)-(muND*ratr*ND*I*b*eps) - (del*att*ND))*(PRDACCN/ND)- (muRD)*(PRDACCN)#*(1-rho4) + #dPSUACC210.dt = - (b*(PSU/N)*ws*(ACC210U)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(ACC210U)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K))+(PSDACC210/Tau)-(b*I*eps*(d1))*(PSUACC210)-(muNU*PSUACCN*(ACC210NU/NU)*I*b*eps)-(muSU*PSUACC210)-(PSUACC210*(1/(8*365))) + #dPSDACC210.dt = - (b*(PSU/N)*ws*(ACC210D)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(ACC210D)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K))-(PSDACC210/Tau)+(b*I*eps*(d1))*(PSUACC210)-(muND*PSDACCN*(ACC210ND/ND)*I*b*eps)-(muSD*PSDACC210)-(PSDACC210*(1/(8*365))) + #dPRUACC210.dt = - (b*(PRU/N)*h*(ACC210U)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PRD/N)*h*(ACC210U)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K))+(PRDACC210/Tau)-(b*I*eps*(d1))*(PRUACC210)-(muNU*PRUACCN*(ACC210NU/NU)*I*b*eps)-(muRU*PRUACC210)-(PRUACC210*(1/(8*365))) + #dPRDACC210.dt = - (b*(PRU/N)*h*(ACC210D)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PRD/N)*h*(ACC210D)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K))-(PRDACC210/Tau)+(b*I*eps*(d1))*(PRUACC210)-(muND*PSDACCN*(ACC210ND/ND)*I*b*eps)-(muRD*PRDACC210)-(PRDACC210*(1/(8*365))) + #dACC210U.dt = del*(0.9)+(ACC210D/Tau)-(ACC210U*b*I*eps*d1)-(ACC210NU*muNU*I*b*eps) - (ACC210U*(1/(8*365))) + #dACC210D.dt = -(ACC210D/Tau)+ (ACC210U*b*I*eps*d1)-(ACC210ND*muND*I*b*eps) - (ACC210D*(1/(8*365))) + #dACC210NU.dt = del*(0.9)*(ACC210NU/ACC210U)+(ACC210ND/Tau)-(ACC210NU*b*I*eps*d1)-(ACC210NU*muNU*I*b*eps)- (ACC210NU*(1/(8*365))) + #dACC210ND.dt = -(ACC210ND/Tau)+ (ACC210NU*b*I*eps*d1)-(ACC210ND*muND*I*b*eps)- (ACC210ND*(1/(8*365))) + dPSUACCN2.dt = - (b*(PSU/N)*ws*(NU)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(NU)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K))+(ND/Tau)*(PSDACCN2/ND)+(-(b*I*eps*NU*(d1+rho1))-(muNU*NU*I*b*eps) - (del*att*NU))*(PSUACCN2/NU)#*(1-rho3) + dPSDACCN2.dt = - (b*(PSU/N)*ws*(ND)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(ND)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) +(b*I*eps*NU*d1)*(PSUACCN2/NU)+ (-(ND/Tau)-(ratr*b*I*eps*ND*rho2)-(muND*ratr*ND*I*b*eps) - (del*att*ND))*(PSDACCN2/ND)- (muSD)*(PSDACCN2)#*(1-rho4) + dPRUACCN2.dt = - (b*(PRU/N)*h*(NU)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PRD/N)*h*(NU)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) +(ND/Tau)*(PRDACCN2/ND)+(-(b*I*eps*NU*(d1+rho1))-(muNU*NU*I*b*eps) - (del*att*NU))*(PRUACCN2/NU)#*(1-rho3) + dPRDACCN2.dt = - (b*(PRU/N)*h*(ND)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PRD/N)*h*(ND)*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) + (b*I*eps*NU*d1)*(PRUACCN2/NU)+ (-(ND/Tau)-(ratr*b*I*eps*ND*rho2)-(muND*ratr*ND*I*b*eps) - (del*att*ND))*(PRDACCN2/ND)#*(1-rho4) + dPSUACC.dt = - (b*(PSU/N)*ws*(SU*(meanstrainsS1+omega1))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(SU*(meanstrainsS1+omega1))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K))+(b*I*eps*NU*rho1)*(PSUACCN2/NU)+(SD/Tau)*(PSDACC/SD)+(-(b*I*eps*SU*((d2*(meanstrainsS4+omega1))+(eta))) - (del*att*SU))*(PSUACC/SU)#*(1-rho3) + dPSDACC.dt = - (b*(PSU/N)*ws*(SD*(meanstrainsS2+omega1))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(SD*(meanstrainsS2+omega1))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K))+(ratr*b*I*eps*ND*rho2)*(PSDACCN2/ND)+(b*I*eps*SU*d2*(meanstrainsS4+omega1))*(PSUACC/SU)+ (-(SD/Tau)-(ratr*b*I*eps*SD*eta) - (del*att*SD))*(PSDACC/SD)- (muSD)*(PSDACC)#death rate included because of clearance by drugs rather than immune system + dPRUACC.dt = - (b*(PRU/N)*h*(SU*(meanstrainsS3+omega1))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PRD/N)*h*(SU*(meanstrainsS3+omega1))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) + (b*I*eps*NU*rho1)*(PRUACCN2/NU)+(SD/Tau)*(PRDACC/SD)+(-(b*I*eps*SU*((d2*(meanstrainsS4+omega1))+(eta))) - (del*att*SU))*(PRUACC/SU)#*(1-rho3) + dPRDACC.dt = - (b*(PRU/N)*h*(SD*(meanstrainsS4+omega1))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PRD/N)*h*(SD*(meanstrainsS4+omega1))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) + (ratr*b*I*eps*ND*rho2)*(PRDACCN2/ND)+(b*I*eps*SU*d2*(meanstrainsS4+omega1))*(PRUACC/SU)+ (-(SD/Tau)-(ratr*b*I*eps*SD*eta) - (del*att*SD))*(PRDACC/SD)#*(1-rho4) + dPSUACCA.dt = - (b*(PSU/N)*ws*(AU*(meanstrainsS5+omega1))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(AU*(meanstrainsS5+omega1))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K))+(AD/Tau)*(PSDACCA/AD)+(b*I*eps*SU*eta)*(PSUACC/SU)-(b*I*eps*(meanstrainsS5)*AU*d3)*(PSUACCA/AU) - (del*att*AU)*(PSUACCA/AU) + dPSDACCA.dt = - (b*(PSU/N)*ws*(AD*(meanstrainsS6+omega1))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*ws*(AD*(meanstrainsS6+omega1))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K))+(ratr*b*I*eps*SD*eta)*(PSDACC/SD)+(b*I*eps*(omega1)*AU*d3)*(PSUACCA/AU)-(AD/Tau)*(PSDACCA/AD) - (del*att*AD)*(PSDACCA/AD) - (muSD)*(PSDACCA) + dPRUACCA.dt = - (b*(PRU/N)*h*(AU*(meanstrainsS5+omega1))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PRD/N)*h*(AU*(meanstrainsS5+omega1))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K))+(AD/Tau)*(PRDACCA/AD)+(b*I*eps*SU*eta)*(PRUACC/SU)-(b*I*eps*(omega1)*AU*d3)*(PRUACCA/AU)- (del*att*AU)*(PRUACCA/AU) + dPRDACCA.dt = - (b*(PRU/N)*h*(AD*(meanstrainsS6+omega1))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K)) - (b*(PSD/N)*h*(AD*(meanstrainsS6+omega1))*(1/K)*(((PSU+PSD+PRU+PRD)/N)-K))+(ratr*b*I*eps*SD*eta)*(PRDACC/SD)+(b*I*eps*(omega1)*AU*d3)*(PRUACCA/AU)-(AD/Tau)*(PRDACCA/AD) - (del*att*AD)*(PRDACCA/AD) + #dNUACC.dt = del+(ND/Tau)#-(b*I*eps*NU*(d1+rho1)) + #dNDACC.dt = (b*I*eps*NU*d1)-(ND/Tau)#-(ratr*b*I*eps*ND*rho2) + return(list(c(dPSU.dt,dPSD.dt,dPRU.dt,dPRD.dt,dNU.dt,dND.dt,dSU.dt,dSD.dt,dAU.dt,dAD.dt,dbeta.dt,dPSUACCN2.dt,dPSDACCN2.dt,dPRUACCN2.dt,dPRDACCN2.dt,dPSUACC.dt,dPSDACC.dt,dPRUACC.dt,dPRDACC.dt,dPSUACCA.dt,dPSDACCA.dt,dPRUACCA.dt,dPRDACCA.dt))) + }) +} + +bavgnull = 1 + +nstrains = 20 + +del = 1 +att = 1/365/30#.000000000001 +muND = 0.1 +muNU = 0.1 +rho1 = 0.5#prob of immunity gain from NU to SU +rho2 = 0.5#prob of immunity gain from ND to SD +rho3 = 1/nstrains #prob of immunity gain from SU to AU +rho4 = rho3#=1/nstrains #prob of immunity gain from SD to AD +omega1 = 1/100 #prob of appearance of new antigen +omega2 = omega1 #prob of appearance of new antigen only in resistant strains + + +L = 1 + +ws = 1 +wr = 1-0.6 +#muSU = 1 +muSU=1/150#0.001 +#muSD = 20 +muSD=0.99 +#muRD = 1 +muRD = muSU#0.001 +#muRU = 1 +muRU = muSU#0.001 +Tau = 20#/365 +d1 = 1 +d2 = d1#/6 +d3 = d1#/10 +#m = 3 +K=10 +p2 = list(bavgnull=bavgnull,ws=ws,wr=wr,muSU=muSU,muSD=muSD,muRD=muRD,muRU=muRU,Tau=Tau,d1=d1,d2=d2,d3=d3,del=del,muND=muND,muNU=muNU,rho1=rho1,rho2=rho2,rho3=rho3,rho4=rho4,omega1=omega1,omega2=omega2,L=L,att=att, K=K) + + +t2 = seq(from=0,to=40000,by=1) + + +N0 = c(500,500,500,500,333,333,333,333,333,333,bavgnull+bavgnull*L,200,200,200,200,200,200,200,200,200,200,200,200)#,100,100,70,70,150,150,150,150,500,500,500,500)#,500,500,500,500,150,150,150,150,200,200,200,200) +out2 = ode(y=N0,times=t2,func=SEAI,parms=p2) +P<-rowSums(out2[,2:5]) +N<-rowSums(out2[,6:11]) +#plot(out2[,1],(out2[,2]+out2[,3]+out2[,4]+out2[,5])) +I<-1-P/N/K +PS<-rowSums(out2[,2:3]) +PR<-rowSums(out2[,4:5]) +eps<-(PS+wr*PR)/N +plot(out2[,1],I,type="l", xlab="Time", ylab="I") +plot(out2[,1],I*eps,type="l", xlab="Time", ylab="I*eps") + +plot(out2[,1],(out2[,2]),type="l", xlab="Time", ylab="Population", main = paste("b=",b,", d=",d1)) +lines(out2[,1],(out2[,3]),col="RED") +legend("bottomright",legend=c("PSU","PSD"),bty="n",lwd = c(2,1),col=c("BLACK","RED")) + +plot(out2[,1],(out2[,4]),type="l", ylim = c(0,max(out2[,5])),xlab = "Time", ylab="Population", main = "b=0.2239*365,d=0.30") +lines(out2[,1],(out2[,5]),col="RED") +legend("bottomright",legend=c("PRU","PRD"),bty="n",lwd = c(2,1),col=c("BLACK","RED")) + +plot(out2[,1],(out2[,12]),type="l", xlab = "Time", ylab="I", main = "b=0.2239*365,d=0.30") +plot(out2[,1],(out2[,13]),type="l", xlab = "Time", ylab="eps", main = "b=0.2239*365,d=0.30") + +#parasite host ratio +plot(out2[,1],apply(out2[,2:5],1,sum)/apply(out2[,6:11],1,sum),type="l", xlab="Time", ylab="parasite/hosts", main = paste("b=",b,", d=",d1)) + +plot(out2[,1],(out2[,6]),ylim=c(0,max(out2[,6])),type="l", xlab="Time", ylab="Population", main = "b=0.2239*365,d=0.30") +lines(out2[,1],(out2[,7]),col="RED") +legend("bottomright",legend=c("NU","ND"),bty="n",lwd=c(2,1),col=c("BLACK","RED")) + +plot(out2[,1],(out2[,8]),ylim=c(0,max(out2[,8])),type="l", xlab="Time",ylab="Population", main = "b=0.2239*365,d=0.30") +lines(out2[,1],(out2[,9]),col="RED") +legend("bottomright",legend=c("SU","SD"),bty="n",lwd=c(2,1),col=c("BLACK","RED")) + +plot(out2[,1],out2[,10],type="l",xlab="Time",ylab="Asymptomatic Population (A)", main="b=0.2239*365,d=0.30") +lines(out2[,1],out2[,11],col="RED") + +plot(out3[,1],out3[,12],xlim=c(0,2000)) + +plot(out2[,1],out2[,17],type="l") +plot(out2[,1],out2[,18],type="l") +plot(out2[,1],out2[,19],type="l") +plot(out2[,1],out2[,20],type="l") + +plot(out2[,1],out2[,21],type="l") +plot(out2[,1],out2[,22],type="l") +plot(out2[,1],out2[,23],type="l") +plot(out2[,1],out2[,24],type="l") + + + + +I1 = (1/(K*(out3[,6]+out3[,7]+out3[,8]+out3[,9]+out3[,10]+out3[,11])))*(-(((out3[,3]+out3[,2]+out3[,4] + out3[,5])/(out3[,6]+out3[,7]+out3[,8]+out3[,9]+out3[,10]+out3[,11]))-K)) + +plot(out2[,1],I1) + +out3eq = matrix(data=0,nrow=6,ncol=366) +out3eq2 = matrix(data=0,nrow=6,ncol=366) +#out3eq3 = vector(mode = "numeric", length = 22) +#out3eq4 = vector(mode = "numeric", length = 22) +#out3eq5 = vector(mode="numeric", length=22) +#out3eq6 = vector(mode="numeric", length=22) +out3eq7 = matrix(data=0,nrow=6,ncol=366) +m = matrix(data=0,nrow=6,ncol=366) +Ivec = vector(mode="numeric",length = 6) +mavg = vector(mode="numeric",length=6) +favg = vector(mode="numeric",length=6) +mnavg = vector(mode="numeric",length=19) +#K = c(0,1,2,3,4,5,6,7,8,9,10) +#out4 = vector(mode="numeric", length=22) +#bvalues = c(0,0.0001,0.0005,0.05,0.10,0.15,0.20,0.25,0.27,0.30,0.32,0.35,0.37,0.40,0.45,0.50,0.55,0.60,0.70,0.80,0.90,1) +#bvalues = c(-4,-3.5,-3,-2.8,-2.5,-2.2,-2,-1.9,-1.7,-1.5,-1.2,-1.1,-1,-0.9,-0.8,-0.6,-0.4,-0.2,-0.1,0,2,4) +#bvalues = c(0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24) +bvalues = seq(from=-1.95,to=-1.45,by=0.025) +wrvalues = c(0,0.10,0.15,0.20,0.25,0.27,0.30,0.32,0.35,0.37,0.40,0.45,0.50,0.55,0.60,0.65,0.70,0.75,0.80,0.85,0.90,1) +dvalues = c(0,0.10,0.15,0.20,0.25,0.27,0.30,0.32,0.35,0.37,0.40,0.45,0.50,0.55,0.60,0.65,0.70,0.75,0.80,0.85,0.90,1) +muSUvalues = c(0,0.10,0.15,0.20,0.25,0.27,0.30,0.32,0.35,0.37,0.40,0.45,0.50,0.55,0.60,0.65,0.70,0.75,0.80,0.85,0.90,1) +delvalues = c(10,20,40,50,60,70,90,100,150,200,250,300,350,400,450,500,550,600,700,800,900,1000) +rho3values = c(0.0005,0.001,0.002,0.003,0.004,0.005,0.006,0.007,0.008,0.009,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.10,0.11,0.12) +omegavalues = c(0.01,0.012,0.014,0.016,0.018,0.02,0.022,0.024,0.026,0.028,0.030,0.032,0.034,0.036,0.038,0.040,0.042,0.044,0.046,0.048,0.050,0.052) +for (i in 1:6){ + #del=delvalues[i] + bavgnull=10^(bvalues[i]) + #wr=wrvalues[i] + #d1=dvalues[i] + #muSU = muSUvalues[i]*0.1 + #rho3 = rho3values[i] + #omega1 = omegavalues[i] + wr=1-0.9 + K = 10 + p2 = list(bavgnull=bavgnull,ws=ws,wr=wr,muSU=muSU,muSD=muSD,muRD=muRD,muRU=muRU,Tau=Tau,d1=d1,d2=d2,d3=d3,del=del,muND=muND,muNU=muNU,rho1=rho1,rho2=rho2,rho3=rho3,rho4=rho4,omega1=omega1,omega2=omega2,L=L,att=att) + N0 = c(500,500,500,500,333,333,333,333,333,333,bavgnull+bavgnull*L,200,200,200,200,200,200,200,200,100,100,70,70)#,500,500,500,500,150,150,150,150,200,200,200,200) + out3 = ode(y=N0,times=t2,func=SEAI,parms=p2) + out3eq[i,] = out3[39635:40000,3]+out3[39635:40000,2] +out3[39635:40000,4] + out3[39635:40000,5] + #out3eq2[i,] = (out3[39635:40000,4]+out3[39635:40000,5])/(out3[39635:40000,2] + out3[39635:40000,3] + out3[39635:40000,4] + out3[39635:40000,5]) + #out3eq3[i] = out3[399999,6]+out3[399999,7] + #out3eq4[i] = out3[399999,8]+out3[399999,9] + #out3eq5[i] = out3[399999,10]+out3[399999,11] + #out4 [i] = (1/(K*(out3[399999,6]+out3[399999,7]+out3[399999,8]+out3[399999,9]+out3[399999,10]+out3[399999,11])))*(-(((out3[3999,3]+out3[3999,2]+out3[3999,4] + out3[3999,5])/(out3[3999,6]+out3[3999,7]+out3[3999,8]+out3[3999,9]+out3[3999,10]+out3[3999,11]))-K)) + #out4[i] = (1/(K*(K)))*(-(((out3[3999,3]+out3[3999,2]+out3[3999,4] + out3[3999,5])/(out3[3999,6]+out3[3999,7]+out3[3999,8]+out3[3999,9]+out3[3999,10]+out3[3999,11]))-K)) + #out3eq6[i] = (out3[3999,7]+out3[3999,9]+out3[3999,11])/(out3[3999,6]+out3[3999,7]+out3[3999,8]+out3[3999,9]+out3[3999,10]+out3[3999,11]) + out3eq7[i,] = (out3[39635:40000,6]+out3[39635:40000,7]+out3[39635:40000,8]+out3[39635:40000,9]+out3[39635:40000,10]+out3[39635:40000,11]) + m[i,] = out3eq[i,]/out3eq7[i,] + mavg[i] = mean(1 - exp(-m[i,])) + #mnavg[i] = mean(1-exp(-(out3[39635:40000,17]+out3[39635:40000,18] +out3[39635:40000,19] + out3[39635:40000,20])/(out3[39635:40000,21]+out3[39635:40000,22]))) + #ptwo = m[i]/(K-1) + #pthree = m[i]/(K-2) + #pfour = m[i]/(K-3) + #pfive = m[i]/(K-4) + #psix = m[i]/(K-5) + #pseven = m[i]/(K-6) + #peight = m[i]/(K-7) + #pnine = m[i]/(K-8) + #pten = m[i]/(K-9) + #Ivec[i] = dnbinom(K,size=1,prob=pone) + #favg[i] = mean(out3eq2[i,]) +} + +#plot(bvalues,out3eq2,xlab="b/10",ylab="Proportion resistant") +#plot(bvalues,1-out4)#,ylab="Proportion Resistant") +plot(bvalues,mavg)#,type="l") +#plot(bvalues,mavg,type="l") +#print(favg) +print(mavg) +plot(mavg,favg) + +#rho3values = c(1/20,1/50,1/100,1/250,1/400,1/500,1/750,1/1000,1/1250,1/1500) +rho3values = seq(from = 0.005, to = 0.05, by = 0.005) +mat6 = matrix(data=0,nrow=10,ncol=21) +etavalues = seq(from=0.01,to=0.21,by=0.04) +#mat77 = matrix(data=0,nrow=10,ncol=19) +#mat7 = matrix(data=0,nrow=10,ncol=6) +#mat8 = matrix(data=0,nrow=22,ncol=22) +#mat9 = matrix(data=0,nrow=22,ncol=22) +#mat10 = matrix(data=0,nrow=22,ncol=22) +#mat11 = matrix(data=0,nrow=22,ncol=22) +#mat12 = matrix(data=0,nrow=22,ncol=22) +for (i in 5:6){ + for (j in 1:21){ + #d = dvalues[i] + # A = Avalues[j] + #rho3=rho3values[i] + #rho4=rho3 + rho3 = rho3values[i] + rho4=rho3 + eta = 0.05 + #wr = wrvalues[i] + wr=1-0.9 + #muSU = muSUvalues[i]*0.01 + bavgnull = 10^(bvalues[j]) + #omega1 = omegavalues[j] + p2 = list(eta=eta,bavgnull=bavgnull,ws=ws,wr=wr,muSU=muSU,muSD=muSD,muRD=muRD,muRU=muRU,Tau=Tau,d1=d1,d2=d2,d3=d3,del=del,muND=muND,muNU=muNU,rho1=rho1,rho2=rho2,rho3=rho3,rho4=rho4,omega1=omega1,omega2=omega2,L=L,att=att) + N0 = c(500,500,500,500,333,333,333,333,333,333,bavgnull+bavgnull*L,200,200,200,200,200,200,200,200,200,200,200,200)#,100,100,70,70,150,150,150,150,500,500,500,500)#,500,500,500,500,150,150,150,150,200,200,200,200) + out5 = ode(y=N0,times=t2,func=SEAI,parms=p2) + # PTotal = out5[3999,2] + out5[3999,3] + out5[3999,4] + out5[3999,5] + # mat[i,j] = (out5[3999,4] + out5[3999,5])/PTotal + #mat2[i,j] = (out5[3999,2] + out5[3999,3] + out5[3999,4] + out5[3999,5])/6000 + #mat3[i,j] = out5[3999,6]/out5[3999,7] + mat6[i,j] = mean((out5[39635:40000,4]+out5[39635:40000,5])/(out5[39635:40000,2] + out5[39635:40000,3] + out5[39635:40000,4] + out5[39635:40000,5])) + #mat7[i,j] = mean(1-exp(-(out5[39635:40000,2]+out5[39635:40000,3]+out5[39635:40000,4]+out5[39635:40000,5])/((out5[39635:40000,6]+out5[39635:40000,7]+out5[39635:40000,8]+out5[39635:40000,9]+out5[39635:40000,10]+out5[39635:40000,11])))) + #mat77[i,j] = mean(1-exp(-(out5[39635:40000,17]+out5[39635:40000,18] +out5[39635:40000,19] + out5[39635:40000,20])/(out5[39635:40000,21]+out5[39635:40000,22]))) + #mat8[i,j]=(out5[3999,10]+out5[3999,11])/(out5[3999,6]+out5[3999,7]+out5[3999,8]+out5[3999,9]+out5[3999,10]+out5[3999,11]) + #mat9[i,j] = (out5[3999,8]+out5[3999,9])/(out5[3999,6]+out5[3999,7]+out5[3999,8]+out5[3999,9]+out5[3999,10]+out5[3999,11]) + #mat10[i,j] = (out5[3999,6]+out5[3999,7])/(out5[3999,6]+out5[3999,7]+out5[3999,8]+out5[3999,9]+out5[3999,10]+out5[3999,11]) + #mat11[i,j] = (out5[3999,6]+out5[3999,7]+out5[3999,8]+out5[3999,9]+out5[3999,10]+out5[3999,11]) + #mat12[i,j]=(out5[3999,7]+out5[3999,9]+out5[3999,11])/(out5[3999,6]+out5[3999,7]+out5[3999,8]+out5[3999,9]+out5[3999,10]+out5[3999,11]) + } +} +print(mat6) +#print(mat7) +#print(mat77) +#print(mat8) +#print(mat9) +#print(mat10) +#print(mat11) +#print(mat12) + +plot(bvalues,mat6[1,],type="l",ylim=c(0,1)) +lines(bvalues,mat6[2,]) +lines(bvalues,mat6[3,]) +lines(bvalues,mat6[4,]) +lines(bvalues,mat6[5,]) +lines(bvalues,mat6[6,]) +lines(bvalues,mat6[7,]) +lines(bvalues,mat6[8,]) +lines(bvalues,mat6[9,]) +lines(bvalues,mat6[10,]) + +plot(bvalues,mat77[9,],type="l",ylim=c(0,1)) +lines(bvalues,mat77[2,],col="RED") +lines(bvalues,mat77[3,],col="GREEN") +lines(bvalues,mat77[4,],col="BLUE") +lines(bvalues,mat77[5,]) +lines(bvalues,mat77[6,]) +lines(bvalues,mat77[7,]) +lines(bvalues,mat77[8,]) +lines(bvalues,mat77[9,]) +lines(bvalues,mat77[10,]) + +plot(mat77[1,],mat6[1,]) +plot(mat77[2,],mat6[2,]) +plot(mat77[3,],mat6[3,]) +plot(mat77[4,],mat6[4,]) +plot(mat77[5,],mat6[5,]) +plot(mat77[6,],mat6[6,]) + +plot(mat77[9,2:7],mat6[9,]) + +plot(mat77[1,9:12],mat6[1,9:12],type="l",ylim=c(0,1),xlim=c(0,1)) +lines(mat77[2,1:4],mat6[2,1:4]) +lines(mat77[3,5:8],mat6[3,5:8]) + +plot(bvalues,mat7[1,],type="l",ylim=c(0,1)) +lines(bvalues,mat7[2,]) +lines(bvalues,mat7[3,]) +lines(bvalues,mat7[4,]) +lines(bvalues,mat7[5,]) +lines(bvalues,mat7[6,]) +lines(bvalues,mat7[7,]) +lines(bvalues,mat7[8,]) +lines(bvalues,mat7[9,]) +lines(bvalues,mat7[10,]) + +plot(mat7[1,],mat6[1,],type="l",ylim=c(0,1)) +lines(mat7[2,],mat6[2,]) +lines(mat7[3,],mat6[3,]) +lines(mat7[4,],mat6[4,]) +lines(mat7[5,],mat6[5,]) +lines(mat7[6,],mat6[6,]) +lines(mat7[7,],mat6[7,]) +lines(mat7[8,],mat6[8,]) +lines(mat7[9,],mat6[9,]) +lines(mat7[10,],mat6[10,]) + + + + + + + +mat7vec = c(mat7) +mat7.df <- as.data.frame(c(t(mat7vec))) +mat73.df <-cbind(mat7.df,vector50,vector62) + +mat77vec = c(mat77) +mat77.df <-as.data.frame(c(t(mat77vec))) +mat773.df <-cbind(mat77.df,vector50,vector62) +#mat6[3,12] = 0 +#mat6[1,12] = 9.395332e-02 +#mat6[5,11] = 0 +#mat6[6,11] = 0 +mat6vec <- c(mat6) +mat6.df <- as.data.frame(c(t(mat6vec))) +vector50 <- c(rho3values,rho3values,rho3values,rho3values,rho3values,rho3values)#,rho3values,rho3values,rho3values,rho3values,rho3values,rho3values,rho3values,rho3values,rho3values,rho3values,rho3values,rho3values,rho3values) +mat62.df <- cbind(mat6.df,vector50) + +vector60 = matrix(data=0,nrow=6,ncol=10) +for(i in 1:6){ + for(j in 1:10){ + vector60[i,] <- rep(bvalues[i],10) + } +} +vector62 <- c(t(vector60)) +mat63.df <- cbind(mat62.df,vector62) + +rows <- rownames(mat63.df) + +columns <- colnames(mat63.df) +log_transmission_intensity <- vector62 +nstrains_inverse <- vector50 +prevalence <- mat7vec +frequency_resistant <- mat6vec +naive_prevalence <- mat77vec +ggplot(data=mat63.df,mapping=aes(x=log_transmission_intensity,y=frequency_resistant))+geom_line(mapping=aes(color=as.factor(nstrains_inverse))) + +ggplot(data=mat73.df,mapping=aes(x=log_transmission_intensity,y=prevalence))+geom_line(mapping=aes(color=as.factor(nstrains_inverse))) + +mixed.df <-cbind(mat63.df,mat7.df) + +ggplot(data=mixed.df,mapping=aes(x=prevalence,y=frequency_resistant))+geom_line(mapping=aes(color=as.factor(nstrains_inverse)))+geom_smooth()+geom_point() + + +ggplot(data=mat773.df,mapping=aes(x=log_transmission_intensity,y=naive_prevalence))+geom_line(mapping=aes(color=as.factor(nstrains_inverse))) + +ggplot(data=mixed.df,mapping=aes(x=prevalence,y=frequency_resistant)) +geom_line(mapping=aes(color=as.factor(log_transmission_intensity)))+geom_smooth() + +mixed2.df <- cbind(mat63.df,mat77.df) + +ggplot(data=mixed.df,mapping=aes(x=nstrains_inverse,y=frequency_resistant)) +geom_line(mapping=aes(color=as.factor(log_transmission_intensity))) + +ggplot(data=mixed.df,mapping=aes(x=nstrains_inverse,y=frequency_resistant)) +geom_line(mapping=aes(color=as.factor(log_transmission_intensity))) + +ggplot(data=mixed.df,mapping=aes(x=nstrains_inverse,y=prevalence)) +geom_line(mapping=aes(color=as.factor(log_transmission_intensity))) + +ggplot(data=mixed2.df,mapping=aes(x=naive_prevalence,y=frequency_resistant)) + geom_point()+geom_smooth() + +vec600 = vector(mode="numeric",length=6) +vec700 = vector(mode="numeric",length=6) +vec770 = vector(mode="numeric",length=6) +for (i in 1:6){ + vec600[i] = mat6[i,i] + vec700[i] = mat7[i,i] + vec770[i] = mat77[i,i] +} +plot(vec700,vec600) + +require(ggplot2) \ No newline at end of file